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Cross-tissue multicellular coordination and its rewiring in cancer
Bed bugs boomed as the world’s first cities did
AI linked to boom in biomedical papers, infrared contact lenses, and is Earth’s core leaking?
The perfect storm for dust storms, thanks to global warming
Pt migration-lockup in zeolite for stable propane dehydrogenation catalyst
Protein-primed homopolymer synthesis by an antiviral reverse transcriptase
Electricity-driven enzymatic dynamic kinetic oxidation
The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan
Harnessing a noncanonical vestibular input in the head-direction network to rectify age-related navigational deficits
Brain drugs can now cross the once impenetrable blood–brain barrier
Europe can capture the US brain drain — if it acts fast
Observing anyonization of bosons in a quantum gas
Philanthropist gives $90 million to support theoretical physics research
Leinweber Foundation donation will help fund postdocs and graduate students at multiple institutions
China is quietly preparing to build a gigantic telescope
Astronomers are puzzled by the silence over an instrument that could briefly reign as world’s biggest
U.S. aid helped two African countries rein in HIV. Then came Trump
In Lesotho and Eswatini, treatment and prevention cutbacks are hitting pregnant women, children, and teens especially hard
Watch a robot play badminton against human players
Advanced training lets a four-legged robot learn to move around the court with ease
New Zealand, betting on innovation and economic growth, cuts existing science funds
Scientists warn that chronic underfunding and diverting support away from fundamental research may undermine efforts to boost the economy
This weapon was made from a whale carcass nearly 20,000 years ago
Study pushes back human use of whale bones more than 1000 years
Developing nanobodies as allosteric molecular chaperones of glucocerebrosidase function
The enzyme glucocerebrosidase (GCase) catalyses the hydrolysis of glucosylceramide to glucose and ceramide within lysosomes. Homozygous or compound heterozygous mutations in the GCase-encoding GBA1 gene cause the lysosomal storage disorder Gaucher disease, while heterozygous and homozygous mutations are the most frequent genetic risk factor for Parkinson's disease. These mutations commonly affect GCase stability, trafficking or activity. Here, we report the development and characterization of...
Genetically encoded fluorescent reporter for polyamines
Polyamines are abundant and evolutionarily conserved metabolites that are essential for life. Dietary polyamine supplementation extends life-span and health-span. Dysregulation of polyamine homeostasis is linked to Parkinson's disease and cancer, driving interest in therapeutically targeting this pathway. However, measuring cellular polyamine levels, which vary across cell types and states, remains challenging. We introduce a genetically encoded polyamine reporter for real-time measurement of...