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Transcriptomic profiling of senescence effects on blood-brain barrier-related gene expression in brain capillary endothelial cells in a mouse model of paclitaxel-induced chemobrain
Chemotherapy-induced cognitive impairment (CICI), commonly referred to as "chemobrain," is a frequent and debilitating side effect experienced by cancer survivors treated with paclitaxel (PTX). Preclinical models have shown that PTX promotes cerebromicrovascular endothelial cell senescence, leading to chronic blood-brain barrier (BBB) disruption and neuroinflammation. Conversely, the elimination of senescent cells through senolytic therapies has been shown to restore BBB integrity, reduce...
Cisplatin and methotrexate induce brain microvascular endothelial and microglial senescence in mouse models of chemotherapy-associated cognitive impairment
The increasing number of cancer survivors has brought heightened attention to the side effects of cancer therapies, including chemotherapy-related cognitive impairment (CRCI, commonly referred to as "chemobrain"). Cisplatin and methotrexate, commonly used first-line chemotherapeutics in gynecologic oncology for cancers such as breast, ovarian, and bladder cancer, are clinically associated with long-term cognitive deficits. Building on our previous preclinical studies demonstrating that...
Black men in the U.S. who ‘passed’ as white lived longer in 20th century
A better education could explain the improvement in longevity
‘Patent mills’ sell scientists inventorship of bizarre medical devices
Thousands of U.K. “design registrations” sold to Indian academics in past 2 years, new research finds
Move over lithium: Sodium batteries could one day power a green economy
Sodium is cheap and abundant, but the batteries can’t quite match lithium cells—so far
Daily briefing: First in-womb treatment for motor-neuron condition is a success
Author Correction: Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells
Revealed: NIH research grants still frozen despite lawsuits challenging Trump order
AI tool diagnoses diabetes, HIV and COVID from a blood sample
How leading a postdoc network boosted my career prospects
Author Correction: The genetic origin of the Indo-Europeans
Large-scale proteomic analyses of incident Parkinson’s disease reveal new pathophysiological insights and potential biomarkers
Quantum computing requires high-performance software
Science, Volume 387, Issue 6736, February 2025.
Erratum for the Research Article “Building materials could store more than 16 billion tonnes of CO2 annually” by Van Roijen et al.
Science, Volume 387, Issue 6736, February 2025.
Trump’s siege of science: how the first 30 days unfolded and what’s next
Snapshots of acyl carrier protein shuttling in human fatty acid synthase
Rare genetic disorder treated in womb for the first time
Structural dynamics of human fatty acid synthase in the condensing cycle
In Science Journals
Science, Volume 387, Issue 6736, Page 837-839, February 2025.
High-performance computing at a crossroads
Science, Volume 387, Issue 6736, Page 829-831, February 2025.