Skip to main content

Aggregator

Age-related differences in locus coeruleus intensity across a demographically diverse sample

5 months 4 weeks ago
Understanding the trajectory of in vivo locus coeruleus (LC) signal intensity across the adult lifespan and among various demographic groups, particularly during middle age, may be crucial for early detection of neurodegenerative diseases, which begin in the LC decades before symptom onset. Even though pathological changes in the LC are thought to begin in middle age, its characteristics across the adult lifespan, and its consistency and variation across demographic groups, remain not well...
Elizabeth Riley

Deciphering Novel Communication Patterns in T Regulatory Cells From Very Old Adults

5 months 4 weeks ago
Regulatory T cells (Tregs) are important in maintaining tolerance and are key players in immunity. In aging, increased Treg function along with low-grade inflammation has been reported. This dichotomy of enhanced Treg function along with inflammation highlights the importance of understanding Treg biology and communication patterns in the very old. In this proof-of-concept study, we demonstrate that aged Tregs (85 years) do not significantly communicate with CD4^(+) and CD8^(+) T effectors when...
Tegan McTaggart