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CONCLUSIONS: Diabetes and cancer were both associated with an increased frailty prevalence; however, only older adults with diabetes or cooccurring diabetes and cancer had an increased 9-year incidence of frailty relative to older adults without a history of either condition. Future research should explore the underlying mechanisms driving frailty state transitions among chronic disease populations and evaluate targeted interventions to mitigate frailty progression.

CONCLUSION: This study contributes valuable evidence supporting psychosocial interventions for active aging. To advance this field, further research should focus on the long-term impact, cultural adaptability, and multimodal strategies that comprehensively address physical, cognitive, and social domains.

Transcriptome analysis has become increasingly utilized in aging research. However, the identification of the key molecular changes underlying aging processes and longevity-promoting regimens from transcriptome data remains challenging. Here, we present Transcriptomic CLassification via Adaptive learning of Signature States (T-CLASS), an online tool that identifies, from transcriptome data, gene sets of several hundred genes that provide an optimal representation of longevity and aging...

Many topics on Bhattacharya’s list are familiar, but order to re-evaluate grants draws concerns

Possible lungfish tracks could push back animal migration onto land by 10 million years

In simulations, AI-generated users of stripped-down social media without content algorithms still split into polarized echo chambers

One technique was practiced significantly earlier than some researchers believe

Researchers isolated signals from a brain implant so people with movement disorders could voice thoughts without trying to speak

No abstract

Alzheimer's disease and related dementias (AD/ADRDs) pose a significant global public health challenge. To effectively implement personalized therapeutic interventions on a global scale, it is essential to identify disease-causing, risk, and resilience factors across diverse ancestral backgrounds. This study leveraged biobank-scale data to conduct a large multi-ancestry whole-genome sequencing characterization of AD/ADRDs. We thoroughly explored the role of protein-coding and splicing variants...

The innate immune system can develop a form of memory called priming, where prior exposure to a stimulus enhances subsequent responses. While well-characterized in peripheral immunity, its function in brain-resident cells such as astrocytes under non-disease conditions remains unclear. Here we show that human astrocytes derived from the induced pluripotent stem cells of healthy female donors, but not microglia, acquire a primed state following transient immune stimulations. Upon subsequent...

Global warming can postpone the autumn date of foliar senescence (DFS). Nevertheless, warming-associated droughts may induce earlier DFS. However, pre-season drought thresholds triggering an earlier DFS (PDT-DFS) are not clearly established. Using site-level DFS data since 1951, satellite-derived DFS data for 1982‒2021, and drought indices, we construct a copula-based Bayesian framework to identify the PDT-DFS over the Northern Hemisphere (>30°N). A higher probability of droughts is associated...

CONCLUSIONS: Reduced HGS and the presence of dynapenia were significantly associated with lower HRQoL, particularly among women. These findings highlight the critical role of muscle strength in maintaining the well-being of aging populations. Further longitudinal studies are warranted to validate these associations and elucidate potential causal mechanisms.

CONCLUSIONS: Caregiver burden is a multidimensional construct with significant implications for caregiver well-being. Key predictors of reduced well-being include self-perceived burden, multifaceted strain, and a diminished sense of life satisfaction. Gender differences were notable, with women reporting higher levels of strain and role overload. These findings underscore the need for comprehensive and gender-sensitive support strategies. Addressing social, financial, physical, and psychological...