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Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging-related phenotypes in mice and macaques
Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice
Rethinking inflammaging across human diversity
China’s shift towards ‘organized research’: how can coordination and innovation co-exist?
Why I study trauma's genetic legacy
AI hype, crackling northern lights and more: take it all in with these holiday reads
Giant radio telescope was ‘a natural magnet’ for African talent
Need to update your data? Follow these five tips
A motorcycle ride through the forest: how I protect Nigeria’s wildlife
Scientists everywhere must be protected
Publisher Correction: Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin
Congressional spending panels continue to push back against proposed Trump research cuts
House committees give a real boost to DOE science and shrink size of cuts to NSF and NASA science
Analysis: Will the government hike indirect cost payments in return for greater accountability?
Under new plan, universities would detail the full cost of research
New study blames diet, not physical inactivity, for obesity crisis
But some scientists warn the research, which compared energy burned across populations, can’t reveal the epidemic’s causes
Countries to budget more for HIV/AIDS measures as U.S. withdraws aid
South Africa plans modest spending increase, but shortfalls will limit prevention and treatment
A chronic low dose of Δ<sup>9</sup>-tetrahydrocannabinol (3 mg / kg / 21 d) reorganizes the disturbed wound healing process and accelerates wound closure in old female mice
Wound healing in old mice is characterized by disturbed tissue homeostasis, manifested by delayed immune cell infiltration and reduced growth factor secretion, leading to a delayed onset and prolonged duration of the inflammatory phase. The endocannabinoid system (ECS) is an important regulator of tissue homeostasis and cell migration and is also considered to be subject to aging processes, which may contribute to observable aging phenomena. Therefore, stimulating the aged ECS could represent a...
Low hand grip strength is associated with increased risk of cognitive impairment in older men, including men with probable sarcopenic obesity: results from the Northern Ireland PRIME-COG cohort
CONCLUSIONS: Probable sarcopenia, indicated by low HGS, was associated with an increased risk of cognitive impairment in older men, with risk consistent across BMI strata, including men living with probable sarcopenic obesity. Our findings have clinical relevance, suggesting that phenotypes comprising low muscle strength, in the presence of excess adiposity must not be overlooked and appropriate interventions explored to attenuate physical perturbations which could carry significance towards...
Bone Anabolic Treatment in Older Subjects: a narrative review
The combination of an increasing life expectancy and an increasing risk of fractures in the aging population collides with the still inadequate primary and secondary fracture prevention in Europe. Osteoporotic fractures have a major impact not only on morbidity, quality of life and mortality but also on healthcare costs. Therefore, an improvement of fracture prevention is warranted. Osteoanabolic drugs are particularly beneficial in patients with very high fracture risk and are recommended by...
Development and Validation of the Care Risk Perception Scale (CRPS) for Caregivers of Older Adults With Dementia in Long-Term Care Facilities
CONCLUSIONS AND IMPLICATIONS: The CRPS is a scientifically robust tool to assess care risk perceptions in LTCFs. By identifying caregivers' risk awareness gaps, it supports targeted interventions and policy reforms for standardized safety audits to enhance dementia care quality and safety.
The Association Between Accelerated Biological Aging and the Physical, Psychological, and Cognitive Multimorbidity and Life Expectancy: Cohort Study
As the global population ages, multimorbidity has become a critical public health issue. We analyzed 332,012 adults from the UK Biobank (2006-2022) to investigate the association between biological age-measured by the Klemera-Doubal method (KDM-BA) and phenotypic age (PhenoAge)-and a new comorbidity model encompassing physical, psychological, and cognitive disorders, with overall mortality outcomes over a median follow-up of 13.6 years. Logistic regression models examined the association between...