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People's brains aged faster during the COVID pandemic - even the uninfected
No abstract
Ageing stem cells in the knees drive arthritis damage
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Differences in patterns of functional and structural connectivity alterations of hippocampal subregions in patients on the Alzheimer's disease spectrum
The present study was conducted to construct structure connectivity (SC) and functional connectivity (FC) between different hippocampal subregions and the whole brain based on structural and function Magnetic Resonance Imaging, and to explore the changes in hippocampal subregions structural and functional connectivity in the different stages of Alzheimer's Disease (AD). 117 participants (75 female, 42 male) aged 60-88 years were recruited from the Sino-Longitudinal Study on Cognitive Decline in...
Demystifying common DNA methylation sites that promote the ability of CheekAge to associate with health and disease
We recently showed that the next-generation epigenetic aging clock CheekAge was significantly associated with 33 different health and disease signals across 25 publicly available MethylationEPIC datasets. We additionally uncovered DNA methylation sites that played a disproportionately important role in driving the ability of CheekAge to associate with each of these variables. We dubbed these "pro" CpGs because of their ability to promote a given association. Here, we identify 2639 common DNA...