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Puzzling objects spotted by NASA’s JWST telescope may be entirely new class of celestial entity

Infecting marine plankton, the pathogen may use its extreme appendage to enter host cells

CONCLUSION: The high prevalence underscores the need for routine screening in health centers and caregiver education programs.

No abstract

Specialized ribosomes help determine which proteins are synthesized, however, the influence of age on ribosome heterogeneity and whether dysregulation of this process drives organismal aging is unknown. Here we examined the role of ribosomal RNA (rRNA) methylation in maintaining appropriate translation as organisms age. In a directed RNAi screen, we identified 18S rRNA N6'-dimethyl adenosine (m^(6,2)A) methyltransferase, dimt-1, as a regulator of C. elegans lifespan and stress resistance. We...

Why education is linked to higher cognitive function in aging is fiercely debated. Leading theories propose that education reduces brain decline in aging and enhances tolerance to brain pathology or that it does not affect cognitive decline but, rather, reflects higher early-life cognitive function. To test these theories, we analyzed 407,356 episodic memory scores from 170,795 participants older than 50 years, alongside 15,157 brain magnetic resonance imaging scans from 6,472 participants...

Reduced peak oxygen uptake (V̇O₂peak) is a hallmark of heart failure (HF) and aging, but studies on V̇O₂peak in older HF patients are limited. We compared V̇O₂peak in older HF patients versus controls and investigated differences across the age continuum: young-old (YO, 60-69 years), middle-old (MO, 70-79 years), and oldest-old (OO, ≥ 80 years). PubMed was searched (1967 May 2024) for studies meeting the following inclusion criteria: (1) HF patients with mean age ≥ 65 years; (2) V̇O₂peak...

This study aimed to investigate the dual-pathway mechanisms underlying cognitive-emotional integration in older adults through a 12-week randomized controlled trial. Specifically, it explored how groove music-integrated Tai Chi (GOTC) modulates cognitive and emotional processes compared to conventional music-based Tai Chi (COTC) and a control group (CON), using functional near-infrared spectroscopy (fNIRS) and surface electromyography (sEMG) to assess prefrontal connectivity and neuromuscular...

DNA methylation data has been used to make "epigenetic clocks" which attempt to measure chronological and biological aging. These models rely on data derived from bisulfite-based measurements, which exploit a semi-selective deamination and a genomic reference to determine methylation states. We found that non-methylation factors lead to "pseudomethylation" signals that are both confounding of epigenetic clocks and uniquely age predictive. We also failed to predict age using human genotyping...

CONCLUSIONS: The need-based educational intervention, along with the educational handbook, has a positive impact on the QoL of older adults. We recommend formal educational sessions with country-specific guidelines for caregivers of activity-limited older adults in the community to improve their QoL.

CONCLUSION: Laparoscopic primary suture of the common bile duct avoids some complications associated with T-tube drainage and offers advantages such as less trauma, faster recovery, and shorter hospital stay. For elderly patients with clear indications, this surgical method is a safe and feasible option.

CONCLUSION: Multidimensional health promotion behaviors are critical factors in the frailty status of Chinese middle-aged and older adults, and there are gender differences in the age-dependent trends in the levels of health promotion behaviors among them with different frailty states. This informs the provision of targeted prevention and intervention services for middle-aged and older adults.