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cTAGE5/MEA6 Regulates LBR Localization to Maintain Nuclear Envelope Integrity and Safeguard Against Aging
cTAGE5/MEA6 plays a pivotal role in COPII complex assembly, ER-to-Golgi trafficking, and secretion. However, whether cTAGE5/MEA6 is involved in other cellular functions remains unclear. Here, we show that conditional cTAGE5 knockout results in embryonic lethality during development and premature aging in adult mice. cTAGE5 deficiency leads to abnormal nuclear structure and disturbed cell proliferation in MEF cells. Further mechanistic studies reveal that cTAGE5 localizes not only to the ER exit...
Lower hippocampal volumes at baseline are associated with higher volume loss in healthy elderly
CONCLUSION: Lower baseline hippocampal z-scores are associated with a greater rate of hippocampal atrophy to the follow-up examination. If validated in larger cohorts, these findings could help establish cut-off values for pathological atrophy in cross-sectional studies.
Development and validation of deep learning- and ensemble learning-based biological ages in the NHANES study
INTRODUCTION: Conventional machine learning (ML) approaches for constructing biological age (BA) have predominantly relied on blood-based markers, limiting their scope. This study aims to develop and validate novel ML-based BA models using a comprehensive set of clinical, behavioral, and socioeconomic factors and evaluate their predictive performance for mortality.
Daily briefing: Respiratory illness can ‘wake up’ dormant cancer cells
Intricate origins of ice mummy’s ink revealed
Potato, tomato: the roots of the modern tater
Five rules for technology leapfrogging in Africa
Science, Volume 389, Issue 6759, July 2025.
Erratum for the Policy Forum “No new fossil fuel projects: The norm we need” by F. Green et al.
Science, Volume 389, Issue 6759, July 2025.
Governing novel climate interventions in rapidly changing oceans
Science, Volume 389, Issue 6759, July 2025.
Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans
Science, Volume 389, Issue 6759, July 2025.
Precise targeting of HIV broadly neutralizing antibody precursors in humans
Science, Volume 389, Issue 6759, July 2025.
Silencing mitochondrial gene expression in living cells
Science, Volume 389, Issue 6759, July 2025.
Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution
Science, Volume 389, Issue 6759, July 2025.
Altered translation elongation contributes to key hallmarks of aging in the killifish brain
Science, Volume 389, Issue 6759, July 2025.
Google AI model mines trillions of images to create maps of Earth ‘at any place and time’
The ocean's deepest animal ecosystem
Stress granule clearance mediated by V-ATPase-interacting protein NCOA7 mitigates ovarian aging
My AI chatbot thinks my idea is fundable
How allergens make us cough and wheeze — by poking holes in airway cells
The Columbia deal is a tragic wake-up call
Science, Volume 389, Issue 6760, Page 551-551, August 2025.