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Adaptor protein supersaturation drives innate immune signaling and cell fate
How minute pathogenic signals trigger decisive immune responses is a fundamental question in biology. Classical signaling often relies on ATP-driven enzymatic cascades, but innate immunity frequently employs death fold domain (DFD) self-assembly. The energetic basis of this assembly is unknown. Here, we show that specific DFDs function as energy reservoirs through metastable supersaturation. Characterizing all 109 human DFDs, we identified sequence-encoded nucleation barriers specifically in the...
Role of Succinate Dehydrogenase in Age-Related Th17 Inflammation
Age-related cellular changes negatively impact CD4^(+) T cell function. Our prior work showed that mitochondrial complex II (succinate dehydrogenase [SDH]) expression was upregulated in T cells from older (O) adults (60-80 years old). T cells from older adults also produced higher amounts of cytokines generally considered proinflammatory, such as Th17 cytokines IL-17A/F and IL-21, and the Th-17-supportive cytokine IL-6, compared to T cells from younger (Y) adults (25-40 years old). The objective...
Daily briefing: Tiny bones from Neanderthal fetus point to downfall of the species
These medical X-rays are all deepfakes — and they fool even radiologists
Antimatter has been transported for the first time ever — in the back of CERN’s truck
Can a mouse be cloned indefinitely? Decades-long experiment has answers
‘Zombie cells’ return from the dead — after a genome transplant
Why it’s hard to guess the high note
How DNA in dirt is shaking up the study of human origins
Why AI hasn’t caused a job apocalypse — so far
How the war in Iran is reshaping the energy landscape
UK scraps airborne lab that tracks climate, pollution and weather systems
Salt lakes are shrinking and expanding, causing havoc in conservation
Scientists should join collaborative online editing communities for biodiversity
Marine life is a silent casualty of armed conflicts
Author Correction: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis
NASA plans to send a nuclear-powered spacecraft to Mars in 2028
Spacecraft would release helicopters to explore martian surface
Correction: Gerontology lost in translation from demography to biology of aging and back
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Aging is not a disease: an evolutionary and comparative biological reappraisal
The question of whether aging should be classified as a disease has gained prominence in geroscience, fueled by advances in molecular biology and the aspiration to develop interventions that mitigate age-associated functional decline. However, evolutionary models describe aging as an emergent consequence of declining selection gradients and life-history trade-offs rather than as a deviation from species-typical function. Comparative data across taxa reveal substantial heterogeneity in aging...
Wobble-board instability re-orthogonalizes postural geometry in older adults through exogenous constraint
Postural control is expressed as intermittent organization of center-of-pressure (CoP) motion on a saddle-shaped manifold typically aligned with the anteroposterior (AP) and mediolateral (ML) axes. When task demands reorient postural focus, this saddle rotates away from the AP-ML alignment yet preserves orthogonal axes that indicate directions of greatest and least fractal temporal correlations in sway. Preserved orthogonality appears to reflect a balance between endogenous fractal fluctuations...