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The source of IDH-mutant gliomas
Science, Volume 391, Issue 6781, Page 125-126, January 2026.
In Other Journals
Science, Volume 391, Issue 6781, Page 144-145, January 2026.
Learning to lead
Science, Volume 391, Issue 6781, Page 210-210, January 2026.
Data sharing helps avoid “smoking gun” claims of topological milestones
Science, Volume 391, Issue 6781, Page 137-142, January 2026.
Self-induced Floquet magnons in magnetic vortices
Science, Volume 391, Issue 6781, Page 190-194, January 2026.
Dogs with a large vocabulary of object labels learn new labels by overhearing like 1.5-year-old infants
Science, Volume 391, Issue 6781, Page 160-163, January 2026.
Access to four-membered cyclic sulfinamides by energy transfer catalysis
Science, Volume 391, Issue 6781, Page 202-207, January 2026.
The molecular basis of the binding and specific activation of rhizobial NodD by flavonoids
Science, Volume 391, Issue 6781, Page 184-189, January 2026.
Molecular press annealing enables robust perovskite solar cells
Science, Volume 391, Issue 6781, Page 164-170, January 2026.
Multivalent ligands regulate dimensional engineering for inverted perovskite solar modules
Science, Volume 391, Issue 6781, Page 153-159, January 2026.
Leveraging triatropic rearrangements for stereoselective skeletal reshuffling
Science, Volume 391, Issue 6781, Page 171-178, January 2026.
The paradox of conscientious medicine
Science, Volume 391, Issue 6781, Page 130-130, January 2026.
Rethinking drug use and addiction
Science, Volume 391, Issue 6781, Page 131-131, January 2026.
The Trump administration says some approved childhood vaccines need better studies. Scientists disagree
Rationale for dropping some vaccine recommendations faces skepticism
A precessing jet from an active galactic nucleus drives gas outflow from a disk galaxy
Science, Volume 391, Issue 6788, Page 911-916, February 2026.
How some people get drunk from their own gut bacteria
Largest study so far of people with the rare “autobrewery syndrome” points to more culprit microbes
Alzheimer’s drug developers accuse clinical trial sites of faking data
T3D Therapeutics alleges that contract researchers delivered “medically impossible” results on its candidate drug
Fossils point to common ancestor of modern humans, Neanderthals
Bones from a Moroccan quarry belonged to a hominin that lived when the human lineage was splitting
USP25 inhibition ameliorates Parkinson's disease by restoring mitophagy
Parkinson's disease (PD) is a progressive neurodegenerative disease that casts a significant shadow over global health and the identification of therapeutic targets for PD will empower more effective clinical treatment. The gene encoding the deubiquitinating enzyme USP25 has been identified as a susceptible locus for PD, but the role of USP25 in PD remains unknown. In this study, we found that USP25 exacerbated dopaminergic neuronal loss and motor deficits in murine models of PD by sabotaging...
A distinct subset of stem-cell memory is poised for the cytotoxicity program in CD4<sup>+</sup> T cells in humans
The CD4^(+) cytotoxic T lymphocytes (CD4-CTLs) with cytotoxic potential are reported to be the components of protective immune response in many diseases. However, the lack of understanding about their lineage, molecular character, and cytolytic potential in comparison to CD8^(+)(CD8)-CTLs has restricted their utility. Thus, here, by parallelly analyzing the human peripheral CD4-CTLs and CD8-CTLs, we demonstrate that they are indistinguishable for the cytotoxic program. Furthermore, using an...