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Insights into bridging disciplines and building measures from the Gateway Exposome Coordinating Center workshop
Stress is wrecking your health: how can science help?
How to chart a moral future for space exploration
Science on the catwalk: Iris van Herpen gives gowns a glow up
Deaf scientists hit by drastic NIH cuts — the research community must support them
Expand biobank sampling to three or more generations
Old CO₂ released from rivers complicates evaluations of fossil-fuel emissions
Address Colombia’s brain-health crisis
Support Sudan’s displaced young scientists
Hot air: the most extreme heatwaves are accelerating the fastest
Memory gets a boost from positive emotion
AI challenge to find lost Amazonian civilizations draws critics
Scientists, ethicists, and officials worry the OpenAI-sponsored contest sidesteps archaeological norms
Democrats stage a science fair of canceled grants to show what’s been lost
Partisan fight over Trump cuts heats up as Congress works on 2026 spending bills.
Comprehensive look at U.S. children’s health finds ‘steady decline’
U.S. children are more likely to die than those in other high-income countries, a new analysis confirms
Response to "Reevaluating leucine's effects on Alzheimer's disease: evidence of potential benefits overlooked"
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Tau PET positivity marks early clinical transition in Alzheimer's disease progression
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Acupuncture modulates ovarian senescence through metabolic reprogramming: A multi-omics investigation in chemotherapy - induced POF model
Premature ovarian failure (POF) is a common female endocrine disorder in women, and there is currently no effective pharmacological treatment available. Acupuncture, an important component of traditional Chinese medicine, has demonstrated clinical efficacy in improving ovarian function in patients with POF; however, its underlying mechanisms remain unclear. This study systematically investigated the therapeutic mechanisms of acupuncture in cyclophosphamide (CTX)-induced POF through combined...
Endothelial sensitivity to pro-fibrotic signals links systemic exposure to pulmonary fibrosis
Pulmonary fibrosis (PF) is a life-threatening condition characterised by excessive extracellular matrix deposition and tissue scarring. While much of PF research has focused on alveolar epithelial cells and fibroblasts, endothelial cells have emerged as active contributors to the disease initiation, especially in the context of systemic exposure to pro-fibrotic substances. Here, we investigate early transcriptomic and secretory responses of human umbilical vein endothelial cells (HUVEC) to...
HDAC3-YY1-RAB5A axis remodels AML-supportive niche by modulating mitochondrial homeostasis in bone marrow stromal cells
Recent studies have shown that the interaction between acute myeloid leukemia (AML) and bone marrow stromal cells (BMSCs) plays a vital role in the progression of leukemia and the development of drug resistance, while the underlying mechanisms remain inconclusive. In this study, we found that AML patient-derived BMSCs exhibit a hyperinflammatory phenotype. Histone deacetylase 3 (HDAC3) in BMSCs enhances mitochondrial reactive oxygen species (ROS) production by RAB5A-mediated blockade of...
Nuclear morphometrics coupled with machine learning identifies dynamic states of senescence across age
Cellular senescence is an irreversible state of cell cycle arrest with a complex role in tissue repair, aging, and disease. However, inconsistencies in identifying cellular senescence have led to varying conclusions about their functional significance. We developed a machine learning-based approach that uses nuclear morphometrics to identify senescent cells at single-cell resolution. By applying unsupervised clustering and dimensional reduction techniques, we built a robust pipeline that...