Aggregator
Tooth Loss and 12-Year Mortality Risk in 8494 Older Adults From Ireland
CONCLUSIONS: Edentulism was independently associated with all-cause mortality in a cohort of 8494 men and women from Ireland. Edentulism was significantly associated with respiratory and cancer mortality.
Immunosenescence Profile Is Associated With Increased Susceptibility to Severe COVID-19
In this study, we tested the hypothesis that the immunosenescence profile could account for the disproportional susceptibility of the elderly to severe forms of COVID-19. The immunological profiles of volunteers residing in endemic and non-endemic areas for chronic infectious diseases were analyzed at the early stage of SARS-CoV-2 infection. A unique signature of inflammatory plasma mediators was identified in COVID-19 volunteers when compared to individuals with other flu-like syndromes....
Beyond Longevity: Prioritizing Individualized Care in Older Adults With NSTE-ACS
Four domains guide management choice: geriatric assessment, cardiovascular risk-factor assessment, medical therapy optimization, and angiographic considerations, integrated to tailor management strategies among older adults with NSTE-ACS.
Daily briefing: The world’s first human bladder transplant
AI is more persuasive than people in online debates
World first: ultra-powerful CRISPR treatment trialled in a person
Mother–infant bonds in wild chimpanzees resemble those of humans
AI tool flags people at high risk of post-partum depression
Author Correction: Inhibitory specificity from a connectomic census of mouse visual cortex
Genomics reveals zoonotic and sustained human Mpox spread in West Africa
Author Correction: Soft–hard zwitterionic additives for aqueous halide flow batteries
Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis
Hurricane risk in a changing climate — the role of uncertainty
When the government cancels your research grant, here’s what you can do
Mighty microbes — the invisible forces that can save the world
Exclusive: NIH grant rejections have more than doubled amid Trump chaos
People and dogs team up to protect sea turtles in Cabo Verde
Trump’s science adviser defends funding cuts as a chance to ‘revitalize’ U.S. science
Michael Kratsios says DEI has led to a loss of public trust in universities
30-day forecast? Weather prediction might be able to look beyond 2 weeks
AI models suggest the true limits of the "butterfly effect" remain unknown
PHGDH-mediated serine synthesis in astrocytes supports neuroinflammation by sustaining NADH level to promote histone acetylation
Neuroinflammation contributes to the loss of dopamine neurons and motor dysfunctions in Parkinson's disease (PD). How cell metabolism regulates neuroinflammation by modulating epigenetic modifications is largely unknown. In this study, we found that the expression of phosphoglycerate dehydrogenase (PHGDH) which catalyzes the first step of the de novo serine synthesis pathway was mainly expressed in astrocytes and l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP) injection triggered the...