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A multidimensional distributional map of future reward in dopamine neurons
Molecular gradients shape synaptic specificity of a visuomotor transformation
Milli-spinner thrombectomy
Male mice can grow female organs — if their mothers lack iron
How researchers are shining a light on the ‘invisible’ contributions of small-scale fishers
Dynamic range and precision of hybrid vision sensors
Reply to: False positives in study of memory-related gene expression
False positives in study of memory-related gene expression
Publisher Correction: Metal–support frontier orbital interactions in single-atom catalysis
A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors
Developing a blood-based epigenetic clock for intrinsic capacity
How a mysterious epidemic of kidney disease is killing thousands of young men
Why we should protect the high seas from all extraction, forever
Genomics pioneer fired from firm he founded: ‘It was not easy to domesticate me’
Human factors
Science-integrity project will root out bad medical papers ‘and tell everyone’
New National Academies board will wade into math wars
Gates Foundation grant enables cash-strapped body to create unit seeking to bridge gap between mathematicians and math educators
Some Dead Sea Scrolls are older than researchers thought, AI analysis suggests
But overall, machine learning approach closely matches what human scholars had long suspected about ancient documents
Long-running physics experiment dashes hope of new particles and forces
Muon is just as magnetic as predicted, requiring no new theory to explain
Role of LIMK1-cofilin-actin axis in dendritic spine dynamics in Alzheimer's disease
Dysregulation of dendritic spine dynamics, a process essential for synaptic plasticity and memory, is a hallmark of Alzheimer's disease (AD). Actin dynamics, largely regulated by the LIMK1-cofilin pathway, are central to maintaining structural and functional stability in neurons. In healthy brains, the LIMK1-cofilin-actin axis modulates actin polymerization within dendritic spines, supporting spine growth and plasticity. However, in AD, this pathway is altered, leading to both actin and synaptic...