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Strong, flexible ‘nylon’ made by engineered bacteria for the first time
How a PhD travel fellowship enriched an international cell-biology meeting
‘Science is happening’: Israeli and Palestinian scientists continue collaborations amid conflict
How researchers can work fairly with Indigenous and local knowledge
The untamed river and the Moog: Books in brief
How I connect Colombia’s remote communities to safer water
Author Correction: B-cell-specific checkpoint molecules that regulate anti-tumour immunity
Absence of care among community-dwelling older adults with dementia and functional limitations
A radical manifesto for truth
Don’t wait out four hard years: speak truth to power
I spent two years organizing an international conference. How do I get compensated for my work?
World’s largest telescopes at risk from Chilean energy project, new analysis confirms
Light pollution and turbulence from wind turbines would worsen views of the distant cosmos
DOGE order leads to journal cancellations by U.S. agricultural library
“We can’t do science without these,” one researcher says of the hundreds of journals no longer accessible
Overseas universities see opportunity in U.S. ‘brain drain’
But many U.S.-based scientists seeking to leave may struggle to find positions in countries grappling with funding issues of their own
New antibody studies boost hope for HIV cure
Pioneering trials discover potential strategy to keep virus in check after stopping treatment
Direct measurement of the male germline mutation rate in individuals using sequential sperm samples
Mutations that accumulate in the human male germline with age are a major driver of genetic diversity and contribute to genetic diseases. However, aging-related male germline mutation rates have not been measured directly in germline cells (sperm) at the level of individuals. We developed a study design in which we recalled 23 sperm donors with prior banked samples to provide new sperm samples. The old and new sequential sperm samples were separated by long timespans, ranging from 10 to 33...
Ecological restoration in the Yellow River Basin enhances hydropower potential
Hydropower, an important renewable energy source worldwide, is threatened by reservoir sedimentation. Ecological restoration (ER) can mitigate this by reducing upstream sediment, thereby extending hydropower facilities' lifespan. However, ER may also reduce runoff, potentially diminishing energy generation and complicating its overall impact on hydropower potential. Here, we examine China's Yellow River, once the world's most sediment-laden river, using eco-hydrological and reservoir regulation...
Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum
Changes in β-amyloid (Aβ) and hyperphosphorylated tau (T) in brain and cerebrospinal fluid (CSF) precede Alzheimer's disease (AD) symptoms, making the CSF proteome a potential avenue to understand disease pathophysiology and facilitate reliable diagnostics and therapies. Using the AT framework and a three-stage study design (discovery, replication, and meta-analysis), we identified 2,173 analytes (2,029 unique proteins) dysregulated in AD. Of these, 865 (43%) were previously reported, and 1,164...
Enteric nervous system dysfunction as a driver of central nervous system disorders: The Forgotten brain in neurological disease
The Enteric Nervous System (ENS), often called the "second brain," is a complex network of neurons and glial cells within the gastrointestinal (GI) tract. It functions autonomously while maintaining close communication with the central nervous system (CNS) via the gut-brain axis (GBA). ENS dysfunction plays a crucial role in neurodegenerative and neurodevelopmental disorders, including Parkinson's disease, Alzheimer's disease, and autism spectrum disorder. Disruptions such as altered...
Endothelial TDP-43 depletion disrupts core blood-brain barrier pathways in neurodegeneration
Endothelial cells (ECs) help maintain the blood-brain barrier but deteriorate in many neurodegenerative disorders. Here we show, using a specialized method to isolate EC and microglial nuclei from postmortem human cortex (92 donors, 50 male and 42 female, aged 20-98 years), that intranuclear cellular indexing of transcriptomes and epitopes enables simultaneous profiling of nuclear proteins and RNA transcripts at a single-nucleus resolution. We identify a disease-associated subset of capillary...