Nature Aging
Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice
Senescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program
Plasma proteome profiling identified biomarkers for the differential diagnosis and molecular staging of neurodegenerative dementias
Positioning TERT at the apex of aging
Disruption of CDK4/6–RARα–NF-κB axis attenuates senescence-associated inflammation and improves function during aging and following chemotherapy
Trained immunity links hematopoietic stem cell aging to aging-associated inflammation
Spatiotemporal dynamics of tau extent and load increase in Alzheimer’s disease across four longitudinal cohorts
Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter
Mapping and manipulating aged and senescent microglia
Author Correction: A T<sub>reg</sub>-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver
Delayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle
Therapeutic targeting of the conserved region within the low-complexity domain of TDP-43 is neuroprotective and extends survival in amyotrophic lateral sclerosis mice
Age-related molecular changes that are exercise independent
Modulating IL-11-dependent matrix stiffness to delay ovarian aging
Mapping the network architecture of aging to identify repurposable drug candidates for longevity
Targeting interleukin-11 to slow ovarian aging
Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging
Inhibition of telomere damage signaling restores hematopoiesis and immune function
Associations of proteomic age clocks with lifestyle risk factors, incident chronic diseases and mortality in two European cohorts
Meta-analysis of DNA methylation aging signatures in 17 human tissues
How long will we live? And how much of that time will comprise a healthy life? What is aging, and can we stop or even reverse the aging process? What is the connection between aging and disease? Can we predict the evolving trends in the aging of human populations and prepare our societies for what has been called the Silver Tsunami? These are some of the important questions that the broad field of aging research is trying to address and that together form one of the Grand Challenges of the twenty-first century. The mission of Nature Aging is to provide a unique multidisciplinary, unifying and highly visible publishing platform for the aging-research community. The journal is highly selective yet broad in its coverage, publishing research from across the entire spectrum of the field, ranging from the basic biology of aging to the impact of aging on society. The journal aims to foster interactions among different areas of this diverse field of research and to promote new and exciting ideas within and beyond the research community, to enable synergy and maximize scientific and societal impact.
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