Nature Aging
A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors
Developing a blood-based epigenetic clock for intrinsic capacity
The secretome of senescent monocytes predicts age-related clinical outcomes in humans
hUSI is a robust transcriptome-based cellular senescence prediction tool
Editing epigenetic age
Pace of aging matters for healthspan and lifespan in older adults
A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions
Mid-life adipogenesis
The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan
Harnessing a noncanonical vestibular input in the head-direction network to rectify age-related navigational deficits
Mitochondrial clonal mosaicism encodes a biphasic molecular clock of aging
Body-to-brain insulin and Notch signaling regulates memory through neuronal CREB activity
Pace of Aging analysis of healthspan and lifespan in older adults in the US and UK
Emerging role of mitochondrial calcium levels in cellular senescence and in switching cell fates
Aberrant engagement of P-selectin drives hematopoietic stem cell aging in mice
Endometrial aging is accompanied by H3K27ac and PGR loss
mRNA metabolism regulator human antigen R (HuR) regulates age-related hearing loss in aged mice
Activation of AMPK by GLP-1R agonists mitigates Alzheimer-related phenotypes in transgenic mice
Large-scale plasma proteomic profiling unveils diagnostic biomarkers and pathways for Alzheimer’s disease
GLP-1R agonists protect against Alzheimer’s disease by rewiring energy regulation
How long will we live? And how much of that time will comprise a healthy life? What is aging, and can we stop or even reverse the aging process? What is the connection between aging and disease? Can we predict the evolving trends in the aging of human populations and prepare our societies for what has been called the Silver Tsunami? These are some of the important questions that the broad field of aging research is trying to address and that together form one of the Grand Challenges of the twenty-first century. The mission of Nature Aging is to provide a unique multidisciplinary, unifying and highly visible publishing platform for the aging-research community. The journal is highly selective yet broad in its coverage, publishing research from across the entire spectrum of the field, ranging from the basic biology of aging to the impact of aging on society. The journal aims to foster interactions among different areas of this diverse field of research and to promote new and exciting ideas within and beyond the research community, to enable synergy and maximize scientific and societal impact.
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