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Low-Intensity Pulsed Ultrasound Treatment Selectively Stimulates Senescent Cells to Promote SASP Factors for Immune Cell Recruitment
As emerging therapeutic strategies for aging and age-associated diseases, various biochemical approaches have been developed to selectively remove senescent cells, but how physical stimulus influences senescent cells and its possible application in senolytic therapy has not been reported yet. Here we developed a physical method to selectively stimulate senescent cells via low-intensity pulsed ultrasound (LIPUS) treatment. LIPUS stimulation did not affect the cell cycle, but selectively enhanced...
Characterization of Human Senescent Cell Biomarkers for Clinical Trials
There is an increasing need for biomarkers of senescent cell burden to facilitate the selection of participants for clinical trials. p16^(Ink4a) is encoded by the CDKN2A locus, which produces five variant transcripts in humans, two of which encode homologous p16 proteins: p16^(Inka4a), encoded by p16_variant 1, and p16ɣ, encoded by p16_variant 5. While distinct quantitative polymerase chain reaction primers can be designed for p16_variant 5, primers for p16_variant 1 also measure p16_variant 5...
Deciphering transcription activity of mammalian early embryos unveils on/off of zygotic genome activation by protein translation/degradation
Quantification of transcription activities in mammalian preimplantation embryos is challenging due to a huge amount of maternally stored transcripts and paucity of research materials. Here, we investigate genome-wide transcription activities of mouse and human preimplantation embryos by quantifying elongating RNA polymerase II. Two transcriptional waves are identified in early mouse embryos, with summits at the 2-cell and 8-cell stages. Gene collections with different expression patterns are...
Why do these curious sea spiders bury themselves in the sand?
DNA analysis of stomach contents suggests these peculiar denizens of the deep are looking to munch on hidden microbes
Trump may decide to leave WHO next week. Here are seven possible impacts on the U.S. and the world
Departure would be catastrophic for global health, diminish U.S. influence, and boost China’s role, scientists say
This snake swallows prey five times larger than its head. Watch its secret
Superstretchy skin gives the Gans’s egg-eater the widest gape–to–head size ratio of any known animal
Daily briefing: The brickbats hurled at scientists researching tobacco’s harms
Trump’s science advisers: how they could influence his second presidency
<b>How to trick the immune system into attacking tumours</b>
Revealed: Why the fatal Huntington’s gene takes so long to cause harm
RNA molecule rejuvenates ageing mice by restoring old cells
How to be a brilliant ally to your neurodivergent lab mate
Mines for a clean-energy metal have a surprise climate effect
Why fires spread quickly in modern cities — and how to slow them down
Evolution of interorganismal strigolactone biosynthesis in seed plants
Science, Volume 387, Issue 6731, January 2025.
A panoramic view of cell population dynamics in mammalian aging
Science, Volume 387, Issue 6731, January 2025.
Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis
Science, Volume 387, Issue 6731, January 2025.
Distinct myeloid-derived suppressor cell populations in human glioblastoma
Science, Volume 387, Issue 6731, January 2025.
AI-designed proteins tackle century-old problem — making snake antivenoms
In a ‘shocker’ decision, Japan approves mpox drug that failed in two efficacy trials
Earlier European authorizations for tecovirimat are also being scrutinized in the face of fresh data