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Bedbugs may be the first urban pest
A new study of the insects’ genomes traces their success back to early civilization
Daily briefing: Harvard has had nearly 1,000 research grants cancelled
Fake AI images will cause headaches for journals
End racism in science: there shouldn’t be any argument about this goal
Time-management skills I honed as a PhD student now serve me well in industry
The diet crazes of the nineteenth century
A coordinated cellular network regulates tolerance to food
Mitochondrial clonal mosaicism encodes a biphasic molecular clock of aging
Body-to-brain insulin and Notch signaling regulates memory through neuronal CREB activity
Gripping account of psychology’s cautionary tale is marred by flawed assumptions
Cancer-fighting immune cells could soon be engineered inside our bodies
‘Science saved my life’ — and it must save other at-risk scholars
Global measles eradication goal is urgently needed
The forest space age needs eyes on the ground
Address academic bullying through structural reform
Taking common medicines might matter for cancer treatment
What does Trump’s call for ‘gold standard science’ really mean?
Critics worry new executive order allows political appointees to determine how science is used in policy decisions
The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer's disease
Microglia play a key role in the response to amyloid beta in Alzheimer's disease (AD). In this context, the major transcriptional response of microglia is the upregulation of APOE, the strongest late-onset AD risk gene. Of its three isoforms, APOE2 is thought to be protective, while APOE4 increases AD risk. We hypothesised that the isoforms change gene regulatory patterns that link back to biological function by shaping microglial transcriptomic and chromatin landscapes. We use RNA- and...
Whole-genome sequencing analyses suggest novel genetic factors associated with Alzheimer's disease and a cumulative effects model for risk liability
Genome-wide association studies (GWAS) on Alzheimer's disease (AD) have predominantly focused on identifying common variants in Europeans. Here, we performed whole-genome sequencing (WGS) of 1,559 individuals from a Korean AD cohort to identify various genetic variants and biomarkers associated with AD. Our GWAS analysis identified a previously unreported locus for common variants (APCDD1) associated with AD. Our WGS analysis was extended to explore the less-characterized genetic factors...
Psychological effects of mountainous environments over the life span and potential implications for healthy ageing: A narrative review
BACKGROUND: Healthy ageing is defined as a process of preserving functional capacity to enable well-being in old age. This concept includes both a physical and a psychological component, which can be positively influenced by spending time in nature and being physically active. Mountainous areas offer diverse opportunities to be physically active in a natural environment. However, little research is available on the psychological effects of mountain environments and mountain sports, particularly...