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fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans
Flavin-containing monooxygenases (FMOs) are a conserved family of xenobiotic enzymes upregulated in multiple longevity interventions, including nematode and mouse models. Previous work supports that C. elegans fmo-2 promotes longevity, stress resistance, and healthspan by rewiring endogenous metabolism. However, there are five C. elegans FMOs and five mammalian FMOs, and it is not known whether promoting longevity and health benefits is a conserved role of this gene family. Here, we report that...
Improving cognitive impairment through chronic consumption of natural compounds/extracts: a systematic review and meta-analysis of randomized controlled trials
CONCLUSION: These findings support the potential cognitive benefits of extended (≥6 weeks) supplementation with natural compounds or extracts in individuals with MCI or AD. Further research is warranted to confirm these results and elucidate the underlying mechanisms.
Daily briefing: Scientists use AI to design life-like enzymes from scratch
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Neuroevolution insights into biological neural computation
Science, Volume 387, Issue 6735, February 2025.
Conformational ensembles reveal the origins of serine protease catalysis
Science, Volume 387, Issue 6735, February 2025.
KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
Science, Volume 387, Issue 6735, February 2025.
Enhancer-driven cell type comparison reveals similarities between the mammalian and bird pallium
Science, Volume 387, Issue 6735, February 2025.
Developmental origins and evolution of pallial cell types and structures in birds
Science, Volume 387, Issue 6735, February 2025.
Evolutionary convergence of sensory circuits in the pallium of amniotes
Science, Volume 387, Issue 6735, February 2025.
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Binary and weighted network analysis and its applications to functional connectivity in subjective memory complaints: A resting-state fMRI approach
CONCLUSION: The findings suggest that functional impairments in SMC patients might be associated with disruptions in the global and regional topological organization of the brain's functional connectome, offering new and significant insights into the pathophysiological mechanisms underlying SMC.