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Death Glitch

1 year 4 months ago
Science, Volume 388, Issue 6754, Page 1379-1379, June 2025.

Producing hunger

1 year 4 months ago
Science, Volume 388, Issue 6754, Page 1378-1378, June 2025.
Laura Stark

Hallmarks of stem cell aging

1 year 4 months ago
As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are relatively shielded from some cellular aging mechanisms compared with their differentiated progeny, they remain vulnerable to both intrinsic and extrinsic stressors. In this review, we delineate five cardinal features that characterize aged stem cells and examine how these alterations underlie functional decline across well-studied stem cell...
Thomas A Rando

Quinacrine and rimonabant prolong the life span of Caenorhabditis elegans

1 year 4 months ago
Aging and age-related disorders are significant global health concerns, driving interest in potential preventative strategies. In this study, we established a high-throughput screening system to reveal the effects of quinacrine and rimonabant on lifespan extension in C. elegans. Mechanistically, quinacrine influences the metabolic and immune pathways through the insulin/insulin-like growth factor (IIS) pathway, as it fails to prolong longevity in IIS pathway mutants while boosting the expression...
Qin He