Aggregator
Massively parallel characterization of transcriptional regulatory elements
GZMK-expressing CD8<sup>+</sup> T cells promote recurrent airway inflammatory diseases
The human and non-human primate developmental GTEx projects
Prolonged persistence of mutagenic DNA lesions in somatic cells
Targeting protein–ligand neosurfaces with a generalizable deep learning tool
Continental influx and pervasive matrilocality in Iron Age Britain
All-solid-state Li–S batteries with fast solid–solid sulfur reaction
Episodic and associative memory from spatial scaffolds in the hippocampus
AI-designed antivenoms could help treat lethal snakebites
Pathogenesis of bovine H5N1 clade 2.3.4.4b infection in Macaques
Engineered enzymes for enantioselective nucleophilic aromatic substitutions
GD3 ganglioside checkpoints in immune surveillance of senescent cells
Aging stem cells limit tumorigenesis
<b>Two companies launch Moon missions together: will they make history?</b>
Author Correction: An endosomal tether undergoes an entropic collapse to bring vesicles together
Chief of U.S. particle physics laboratory suddenly steps down
Resignation of Lia Merminga at Fermilab leaves scientists puzzled
The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer's disease
Microglia are progressively activated by inflammation and exhibit phagocytic dysfunction in the pathogenesis of neurodegenerative diseases. Lipid-droplet-accumulating microglia were identified in the aging mouse and human brain; however, little is known about the formation and role of lipid droplets in microglial neuroinflammation of Alzheimer's disease (AD). Here, we report a striking buildup of lipid droplets accumulation in microglia in the 3xTg mouse brain. Moreover, we observed significant...
Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson's disease model mice
Neuroinflammation is a key factor in the pathogenesis of Parkinson's disease (PD). Activated microglia in the central nervous system (CNS) and infiltration of peripheral immune cells contribute to dopaminergic neuron loss. However, the role of peripheral immune responses, particularly triggering receptor expressed on myeloid cells-1 (TREM-1), in PD remains unclear. Using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP)-induced PD mouse model, we examined TREM-1 expression and...
Interplay of p23 with FKBP51 and their chaperone complex in regulating tau aggregation
The pathological deposition of tau and amyloid-beta into insoluble amyloid fibrils are pathological hallmarks of Alzheimer's disease. Molecular chaperones are important cellular factors contributing to the regulation of tau misfolding and aggregation. Here we reveal an Hsp90-independent mechanism by which the co-chaperone p23 as well as a molecular complex formed by two co-chaperones, p23 and FKBP51, modulates tau aggregation. Integrating NMR spectroscopy, SAXS, molecular docking, and...
Multi-omic quantitative trait loci link tandem repeat size variation to gene regulation in human brain
Tandem repeat (TR) size variation is implicated in ~50 neurological disorders, yet its impact on gene regulation in the human brain remains largely unknown. In the present study, we quantified the impact of TR size variation on brain gene regulation across distinct molecular phenotypes, based on 4,412 multi-omics samples from 1,597 donors, including 1,586 newly sequenced ones. We identified ~2.2 million TR molecular quantitative trait loci (TR-xQTLs), linking ~139,000 unique TRs to nearby...