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The double-edged sword of eliminating senescent cells
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When senescence generates pluripotent stem cells
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Cyclophilin D plays a critical role in the survival of senescent cells
Senescent cells play a causative role in many diseases, and their elimination is a promising therapeutic strategy. Here, through a genome-wide CRISPR/Cas9 screen, we identify the gene PPIF, encoding the mitochondrial protein cyclophilin D (CypD), as a novel senolytic target. Cyclophilin D promotes the transient opening of the mitochondrial permeability transition pore (mPTP), which serves as a failsafe mechanism for calcium efflux. We show that senescent cells exhibit a high frequency of...
Prevalence of obsessive-compulsive disorder in the older person: a systematic review and meta-analysis
CONCLUSION: The results of the present study indicate a high prevalence of OCD among the older person. Hence, it is advised that greater attention be directed towards this issue by experts, authorities, and health policymakers.
Can science and Islam coexist? A chemical engineer–turned–theologian sees common ground
Shoaib Ahmed Malik discusses his work on evolution, extraterrestrials, and more
Daily briefing: Specialized genes of new tardigrade species arm it with radiation shield
Study reveals three ways to disappear down a Wikipedia rabbit hole
Will AI’s huge energy demands spur a nuclear renaissance?
Audio long read: Which is the fairest electoral system? Mega-election year sparks debate
Decline after fall, Books in brief
Informant characteristics influence Clinical Dementia Rating Sum of Boxes scores-based staging of Alzheimer’s disease
The Clinical Dementia Rating scale is useful but caution is needed
Do stem-cell transplants increase cancer risk? Long-lived recipients offer clues
Atomic smash-ups hold promise of record-breaking elements
Twenty years of microplastic pollution research—what have we learned?
Science, Volume 386, Issue 6720, October 2024.
The landscape of RNA binding proteins in mammalian spermatogenesis
Science, Volume 386, Issue 6720, October 2024.
Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis
Science, Volume 386, Issue 6720, October 2024.
A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase
Science, Volume 386, Issue 6720, October 2024.
Multi-omics landscape and molecular basis of radiation tolerance in a tardigrade
Science, Volume 386, Issue 6720, October 2024.
Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function
Science, Volume 386, Issue 6720, October 2024.