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The association between statins and gait speed reserve in older adults: effects of concomitant medication

1 year 1 month ago
Statins are frequently prescribed to older adults, yet their effects on ageing phenotypes such as frailty or physiological reserves remain poorly understood. Gait Speed Reserve (GSR), defined as the difference between maximal and usual gait speeds, serves as an indicator of physiological reserve, reflecting the body's ability to perform beyond baseline functional levels. Polypharmacy, prevalent in this population, may contribute to inconsistent findings through interactions between statins and...
Anton De Spiegeleer

Calorie-restriction treatment mitigates the aging in rat liver model

1 year 1 month ago
The aging process promotes progressive impairment of homeostasis and the increase of the risk of disease and death. A major hallmark of the aging process is the systemic chronic inflammation which strongly contributes to the onset of aging-related diseases. In the liver, the aging condition drives the hepatocytes to develop a metabolic dysfunction-associated steatosis. Caloric restriction (CR) is a remarkable strategy to delay biological aging, occurring through several mechanisms. In this study...
L Urlandini

Urban health inequities and healthy longevity: traditional and emerging risk factors across the cities and policy implications

1 year 1 month ago
Urbanization is reshaping global health, with over 55% of the world's population residing in urban areas, a figure projected to reach 68% by 2050. This demographic shift presents significant challenges and opportunities for public health, as urban environments exacerbate health disparities rooted in social determinants of health, such as economic stability, education, neighborhood conditions, and access to healthcare. Rapid urban growth, particularly in low- and middle-income countries, has led...
Stefano Cacciatore

Editing Geriatric Medicine Journals: Perspectives From the Editors-in-Chief of Age and Ageing, European Geriatric Medicine and the Journal of the American Geriatrics Society

1 year 1 month ago
This article has been simultaneously published in Journal of the American Geriatrics Society (published by Wiley Periodicals LLC on behalf of The American Geriatrics Society), Age and Ageing (published by Oxford University Press on behalf of British Geriatrics Society), and European Geriatric Medicine (published by Springer on behalf of European Geriatric Medicine Society). All rights reserved. The articles are identical except for minor stylistic and spelling differences in keeping with each...
Roy L Soiza