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Why the word scientist was controversial 100 years ago
Author Correction: Gamma frequency entrainment attenuates amyloid load and modifies microglia
Age-related decline in CD8<sup>+</sup> tissue resident memory T cells compromises antitumor immunity
Old enlarged nucleoli open the door to the cell’s demise
Affirmative action slow to take hold in Brazil’s graduate science education
Shifting sands threaten flood-mitigation measures
The United States, as a marine superpower, must ratify the high seas biodiversity treaty now
Don’t let watermarks stigmatize AI-generated research content
Attacks on democracy are attacks on science — and vice versa
Evidence of ‘disability bias’ in research grant awards
Turtles map seagrass better than satellites can
Tracing tagged turtles reveals more than 30 new seagrass sites in the Red Sea
Would Trump’s CDC nominee fix the agency’s problems—or create new ones?
If confirmed, physician and former congressman David Weldon would helm an agency dealing with communication challenges and a battered image
‘We’re going to need a lot of solutions’: Global treaty on plastic pollution reaches homestretch
A scientist attending the final negotiations reflects on the challenges of tackling a global problem
Mixed reactions greet Trump’s pick of longtime FDA critic to head agency
Surgeon Martin Makary, who opposed COVID-19 vaccine mandates, may have to choose between public health and politics
Insulin-inspired peptides may open new pathways to treat Alzheimer's disease
No abstract
Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer's disease mice by controlling astrocyte activation
Alzheimer's disease (AD) is the most common form of dementia and is characterized by the accumulation of amyloid β (Aβ) and phosphorylated tau. Neuroinflammation, mainly mediated by glial activation, plays an important role in AD progression. Although there is growing evidence for the anti-neuroinflammatory and neuroprotective effects of the cannabinoid system modulation, the detailed mechanism remains unclear. To address these issues, we analyzed the expression levels of cannabinoid receptor...
Views of aging and subjective cognition in middle-aged and older adults: A systematic review
CONCLUSION: Most studies supported associations between views of aging and subjective cognition. More longitudinal as well as qualitative research is needed to advance understanding of factors that influence these relationships.
Does the digital divide accelerate cognitive function decline related to the poor management of diabetes in later life?
INTRODUCTION: The objective is to investigate the role of digital exclusion in the association between diabetes and cognitive function among adults aged 50 and above.
Fecal microbiota transplantation, a tool to transfer healthy longevity
The complex gut microbiome influences host aging and plays an important role in the manifestation of age-related diseases. Restoring a healthy gut microbiome via Fecal Microbiota Transplantation (FMT) is receiving extensive consideration to therapeutically transfer healthy longevity. Herein, we comprehensively review the benefits of gut microbial rejuvenation - via FMT - to promote healthy aging, with few studies documenting life length properties. This review explores how preconditioning donors...
Alzheimer's Disease polygenic risk, the plasma proteome, and dementia incidence among UK older adults
Alzheimer's Disease (AD) is a complex polygenic neurodegenerative disorder. Its genetic risk's relationship with all-cause dementia may be influenced by the plasma proteome. Up to 40,139 UK Biobank participants aged ≥ 50y at baseline assessment (2006-2010) were followed-up for ≤ 15 y for dementia incidence. Plasma proteomics were performed on a sub-sample of UK Biobank participants (k = 1,463 plasma proteins). AD polygenic risk scores (PRS) were used as the primary exposure and Cox proportional...