Aggregator
Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses
Linking ferroptosis to thymic involution
Mapping aged stem cell states associated with decline in skeletal muscle regeneration
How I’m creating career opportunities for researchers back home in Mexico
Epiphanies
DNA need not apply: Books in brief
Surface restructuring and predictive design of heterogeneous catalysts
Science, Volume 386, Issue 6724, November 2024.
Chemically induced proximity reveals a Piezo-dependent meiotic checkpoint at the oocyte nuclear envelope
Science, Volume 386, Issue 6724, November 2024.
Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes
Science, Volume 386, Issue 6724, November 2024.
Platelet factor 4–induced TH1-Treg polarization suppresses antitumor immunity
Science, Volume 386, Issue 6724, November 2024.
Reconstruction of the human amylase locus reveals ancient duplications seeding modern-day variation
Science, Volume 386, Issue 6724, November 2024.
Scientists uncover hearth Neanderthals may have used to make tar
Researchers re-create process of burning branches to make tarry adhesive to haft stone tools
China poised to turn on one of world’s most powerful sources of x-ray light
Beams from $657 million next-generation synchrotron will reveal atomic-scale structure of proteins and materials
‘I’m really shocked.’ Children not being vaccinated for mpox in Congo
Regulatory and liability issues are delaying immunization of the most vulnerable group
Elected to the House, veteran high school science teacher urges ‘evidence-based’ decision-making
Democrat John Mannion flips New York district with plea for bipartisanship
HLA is a potent immunoinflammatory target in asymptomatic Alzheimer's disease
Alzheimer's disease (AD) is a common neurodegenerative disease, neuroinflammation is an early pathological feature of AD. However, the alteration of the immune microenvironment in asymptomatic AD was not fully explained. In this study, we aimed to utilize the transcriptome data of AD patients in public databases to reveal the change of immune microenvironment in asymptomatic AD and screen the potential drug targets. A series of bioinformatics analyses were done, including differentially...
Whole-genome sequencing to identify rare variants in East Asian patients with dementia with Lewy bodies
Dementia with Lewy bodies (DLB) is the second most common form of age-related dementia, following Alzheimer's disease (AD). DLB is associated with a worse prognosis than AD and is characterized by a more rapid progression of cognitive impairment and a poorer quality of life. In addition, the pathogenesis of DLB is less understood than that of AD, and only three genes-SNCA (α-synuclein), APOE (apolipoprotein E), and GBA1 (glucosylceramidase beta 1)-have been convincingly demonstrated to be...
New schizophrenia drug could treat Alzheimer's disease
No abstract
Exome sequencing in Asian populations identifies low-frequency and rare coding variation influencing Parkinson's disease risk
Parkinson's disease (PD) is an incurable, progressive and common movement disorder that is increasing in incidence globally because of population aging. We hypothesized that the landscape of rare, protein-altering variants could provide further insights into disease pathogenesis. Here we performed whole-exome sequencing followed by gene-based tests on 4,298 PD cases and 5,512 controls of Asian ancestry. We showed that GBA1 and SMPD1 were significantly associated with PD risk, with replication in...
Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease
The abnormal assembly of tau protein in neurons is a pathological hallmark of multiple neurodegenerative diseases, including Alzheimer's disease (AD). Assembled tau associates with extracellular vesicles (EVs) in the central nervous system of individuals with AD, which is linked to its clearance and prion-like propagation. However, the identities of the assembled tau species and EVs, as well as how they associate, are not known. Here, we combined quantitative mass spectrometry, cryo-electron...