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Jay Bhattacharya says NIH’s final budget will be a “collaboration”

Degrading LIGO’s observations of gravitational waves would amount to “killing a newborn baby,” one astrophysicist says

Efforts to improve the rigor of research may have unwittingly handed the administration a way to attack science

Health secretary will soon name new members to expert group that recommends shots

No abstract

Accurate classification of neurodegenerative disorders remains a challenge in neuroscience. Using open-source electroencephalography (EEG) data, we investigated electrophysiological signatures to differentiate frontotemporal dementia (FTD) from Alzheimer's disease (AD) via complexity measures. Traditional relative band power analysis showed consistent increases in lower-frequency activity but did not distinguish the two disorders after correction. In contrast, fractal dimension and long-range...

Genome-wide association studies have identified many gene polymorphisms associated with an increased risk of developing late-onset Alzheimer's disease (LOAD). Many of these LOAD risk-associated alleles alter disease pathogenesis by influencing innate immune responses and lipid metabolism of microglia (MG). Here we show that boosting the expression of angiotensin-converting enzyme (ACE), a genome-wide association study LOAD risk-associated gene product, specifically in MG, reduces amyloid-β (Aβ)...

Telomere shortening occurs in multiple tissues throughout aging. When telomeres become critically short, they trigger DNA-damage responses and p53 stabilization, leading to apoptosis or replicative senescence. In vitro, cells with short telomeres activate the cGAS-STING innate immune pathway resulting in type-I interferon-based inflammation and senescence. However, the consequences of these events for the organism are not yet understood. Here, we show that sting is responsible for premature...

CONCLUSIONS: Empty-nest older adults in the Chinese community show a desirable level of healthy ageing and psychological resilience, yet there is still room for improvement. Those who live with their spouses, have retirement pensions, engage regularly in social activities, and demonstrate strong psychological resilience tend to achieve a higher level of healthy ageing. Policies and strategies could focus on creating a more supportive environment, reducing health inequities among empty-nest older...