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Observed trend in Earth energy imbalance may provide a constraint for low climate sensitivity models
Science, Volume 388, Issue 6752, Page 1210-1213, June 2025.
Antagonism as a foraging strategy in microbial communities
Science, Volume 388, Issue 6752, Page 1214-1217, June 2025.
Differential absorption of circularly polarized light by a centrosymmetric crystal
Science, Volume 388, Issue 6752, Page 1194-1197, June 2025.
RNA transcripts regulate G-quadruplex landscapes through G-loop formation
Science, Volume 388, Issue 6752, Page 1225-1231, June 2025.
Gate-driven band modulation hyperdoping for high-performance p-type 2D semiconductor transistors
Science, Volume 388, Issue 6752, Page 1183-1188, June 2025.
Pan-viral ORFs discovery using massively parallel ribosome profiling
Science, Volume 388, Issue 6752, Page 1218-1224, June 2025.
Rapid model-guided design of organ-scale synthetic vasculature for biomanufacturing
Science, Volume 388, Issue 6752, Page 1198-1204, June 2025.
Dark matters
Science, Volume 388, Issue 6752, Page 1141-1141, June 2025.
North America’s last prairies
Science, Volume 388, Issue 6752, Page 1142-1142, June 2025.
Physicists’ hopes for an exotic muon collider get a boost
U.S. should plan to build machine to hunt for new subatomic particles, National Academies report says
Trump’s cuts to more than 1700 NIH grants get court hearing
District judge could declare terminations unlawful—or toss suit based on technicalities
Tropical forests are heating up. Can they cope?
Scientists are pushing plants beyond their comfort zone to test their resilience to warming
Climate change threatens India-Pakistan pact over major river system
Warming world could further heighten tensions over access to Indus River waters
Historical records expose role of Black inmates in unethical malaria studies decades ago
Science chats with James Tabery about the overlooked role of Black prisoners in understanding the genetics of drug reactions
Newly discovered plant genes could slash cost of making key cancer drug
Shifting production from yew trees to yeast could lead to cheaper synthesis of Taxol precursor
This brain implant lets a man who lost his speech to ALS produce natural-sounding sentences instantaneously
New brain-computer interface allows control of intonation, and generates a person’s voice at the speed of typical speech
‘Dragon prince’ dinosaur may be missing link in <em>T. rex</em> evolution
Newly described fossils point to ancient movement between Asia and North America
Massively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition state
Amyloid aggregates are pathological hallmarks of many human diseases, but how soluble proteins nucleate to form amyloids is poorly understood. Here, we use combinatorial mutagenesis, a kinetic selection assay, and machine learning to massively perturb the energetics of the nucleation reaction of amyloid-β (Aβ42), the protein that aggregates in Alzheimer's disease. In total, we measure the nucleation rates of >140,000 variants of Aβ42 to accurately quantify the changes in free energy of...
Trends and mechanisms of Alzheimer's disease and hearing impairment: A 20-year perspective
Alzheimer's disease (AD) and hearing loss (HL) are major age-related public health challenges with emerging evidence suggesting their interconnection. This study aimed to investigate global research trends, shared molecular mechanisms, and clinical implications of AD and HL. A total of 349 articles published between 2004 and 2024 were retrieved from the Web of Science Core Collection and analyzed using VOSviewer and CiteSpace. GeneCards and STRING databases were used to explore molecular targets...
Sequential transcriptional programs underpin activation of hippocampal stem cells
Adult neural stem cells exist on a continuum from deep to shallow quiescence that changes in response to injury or aging; however, the transcription factors controlling these stepwise transitions have not been identified. Single-cell transcriptomic analyses of mice with loss of function or increased levels of the essential activation factor Ascl1 reveal that Ascl1 promotes the activation of hippocampal neural stem cells by driving these cells out of deep quiescence, despite its low protein...