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A role for RNA knots in Alzheimer's disease
The buildup of knot-like RNA structures in brain cells may be the key to understanding how uncontrolled protein aggregation drives Alzheimer's disease.
The Effect of Advancing Age and Intraocular Pressure Injury on Retinal Ganglion Cell Function and Synaptic Connectivity
Age and elevated intraocular pressure (IOP) are the two major risk factors for developing glaucoma, a leading cause of blindness worldwide that is characterized by the loss of retinal ganglion cells (RGCs). Although vision loss is irreversible over the long term, accumulating evidence points to short-term improvement of vision in glaucoma patients in response to certain interventions, suggesting that RGCs have the capacity to recover function. In the present study, we sought to investigate the...
Organizational Work, Well-Being, and Quality of Life at an Elderly Age: The Case of Cyprus
This study investigates the impact of postretirement organizational work on the well-being and overall quality of life of the elderly population in Cyprus. Specifically, it evaluates the multifaceted effects of continued employment after retirement, based on data collected through a survey administered to a representative sample of elderly Cypriots. The research findings, informed by prominent instruments in the field, demonstrate significant enhancements in autonomy, self-actualization, and...
Daily briefing: Trump administration policies create turmoil for NIH-funded researchers worldwide
Trump team orders huge government lay-offs: how science could fare
How academia’s ‘lone wolf’ culture is harming researcher mental health
Ukraine’s research sector is struggling — can Europe help?
Audio long read: Why kids need to take more risks — science reveals the benefits of wild, free play
Just a smidgen of yellow-fever vaccine is enough
Hydrogenation of CO2 for sustainable fuel and chemical production
Science, Volume 387, Issue 6737, February 2025.
4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis–like lesions
Science, Volume 387, Issue 6737, February 2025.
A widespread plant defense compound disarms bacterial type III injectisome assembly
Science, Volume 387, Issue 6737, February 2025.
Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling
Science, Volume 387, Issue 6737, February 2025.
Distinct roles for precession, obliquity, and eccentricity in Pleistocene 100-kyr glacial cycles
Science, Volume 387, Issue 6737, February 2025.
CASTER: Direct species tree inference from whole-genome alignments
Science, Volume 387, Issue 6737, February 2025.
Mysterious Congo outbreak likely linked to contaminated water, researchers say
Deaths have raised fears that a dangerous new microbe has emerged
‘A bloodbath’: HIV field is reeling after billions in U.S. funding are axed
USAID’s promises to support lifesaving efforts are broken, putting millions in peril
Stars made from only primordial gas finally spotted, astronomers claim
Short-cut method pinpoints a galaxy apparently formed from just hydrogen and helium
NSF downsizes summer research program for undergraduates
Many participants are from groups underrepresented in science
BACE1-dependent cleavage of GABA(A) receptor contributes to neural hyperexcitability and disease progression in Alzheimer's disease
Neural hyperexcitability has been clinically associated with amyloid-β (Aβ) pathology and cognitive impairment in Alzheimer's disease (AD). Here, we show that decreased GABA(A) receptor (GABA(A)R) currents are linked to hippocampal granule cell hyperexcitability in the AD mouse model APP23. Elevated levels of β-secretase (BACE1), the β-secretase responsible for generating Aβ peptides, lead to aberrant cleavage of GABA(A)R β1/2/3 subunits in the brains of APP23 mice and AD patients. Moreover,...