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Australopithecus at Sterkfontein did not consume substantial mammalian meat
Science, Volume 387, Issue 6731, Page 309-314, January 2025.
Climate change and the cost-of-living squeeze in desert lizards
Science, Volume 387, Issue 6731, Page 303-309, January 2025.
Global increase in the occurrence and impact of multiyear droughts
Science, Volume 387, Issue 6731, Page 278-284, January 2025.
Nonalloyed α-phase formamidinium lead triiodide solar cells through iodine intercalation
Science, Volume 387, Issue 6731, Page 284-290, January 2025.
Mechanically interlocked two-dimensional polymers
Science, Volume 387, Issue 6731, Page 264-269, January 2025.
Stereomicrostructure-regulated biodegradable adhesives
Science, Volume 387, Issue 6731, Page 297-303, January 2025.
Tactile edges and motion via patterned microstimulation of the human somatosensory cortex
Science, Volume 387, Issue 6731, Page 315-322, January 2025.
Reconstitution of synaptic junctions orchestrated by teneurin-latrophilin complexes
Science, Volume 387, Issue 6731, Page 322-329, January 2025.
Drought in a warmer, CO2-rich climate restricts grassland water use and soil water mixing
Science, Volume 387, Issue 6731, Page 290-296, January 2025.
Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis
Science, Volume 387, Issue 6731, Page 329-336, January 2025.
Rooting out racial prejudices
Science, Volume 387, Issue 6731, Page 254-254, January 2025.
The ancestral genome’s tale
Science, Volume 387, Issue 6731, Page 253-253, January 2025.
Microscopic pillars on insect wings give bugs an antibacterial superpower
New insights into how these “nanopillars” work could inspire better ways to protect humans from infection
New materials with interlocking parts can flow like liquid or contract like muscles
Made like miniature chainmail armor, these polymers have strange—and useful—properties
Climate change may be driving spread of a deadly fungus from U.S. Southwest
Valley fever has exploded since 2000. Scientists are trying to figure out why (edited)
News at a glance: Oldest continuous ice core, formaldehyde’s risks, and building Africa’s science workforce
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DeepSeek’s open-source answer to ChatGPT is “a highly impressive display of research,” expert says
The ER protein CANX (calnexin)-mediated autophagy protects against alzheimer disease
Although the relationship between macroautophagy/autophagy and Alzheimer disease (AD) is widely studied, the underlying mechanisms are poorly understood, especially the regulatory role of the initiation signaling of autophagy on AD. Here, we find that the ER transmembrane protein CANX (calnexin) is a novel interaction partner of the autophagy-inducing kinase ULK1 and is required for ULK1 recruitment to the ER under basal or starved conditions. Loss of CANX results in the inactivity of ULK1...