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Enhanced focality and intensity in deep brain targeting: In silico study on multi-channel temporal interference stimulation for Parkinson's disease

11 months ago
This study introduces a novel multi-channel temporal interference stimulation (M-TIS) paradigm and rigorously evaluates its capacity to non-invasively target the globus pallidus internus (GPi), a pivotal region in Parkinson's disease (PD) treatment. Employing realistic human head models derived from MRI data and sophisticated finite element modeling, we demonstrate that M-TIS achieves significantly enhanced stimulation intensity and focality within the GPi compared to conventional single-channel...
Bangyu Wang

Smoking Promotes AT2 Cell Senescence and Exacerbates Pulmonary Fibrosis by Downregulating POT1 via Integratively Inducing CpG Methylation and MECP2-Mediated FOXP2 Transcriptional Binding Inhibition

11 months ago
Smoking is one of the most recognized risk factors for pulmonary fibrosis (PF). However, the underlying mechanism is not well understood. This study reveals smoking increases the risk of developing idiopathic PF (IPF) and that smoked IPF patients exhibit higher levels of senescence markers than non-smoker IPF patients. Moreover, smoking enhances bleomycin (Bleo)-induced PF, along with obvious senescence of type II alveolar (AT2) cells. RNA-seq assay identifies cigarette downregulates protection...
Mengkun Shi

Amyloid and tau pathologies cross-talk to promote Alzheimeŕs disease: novel mechanistic insights

11 months ago
Aging-related declines in energy metabolism represent a key risk factor for the development of amyloid pathology, the earliest hallmark of Alzheimer's disease. Aging also contributes to the emergence of the second major hallmark, tau pathology, whose propagation is facilitated by pre-existing amyloid accumulation. The overlap of amyloid and tau pathologies ultimately leads to neurodegeneration and the onset of Alzheimer's disease-the most prevalent form of dementia. Recent findings underscore a...
Jesús Avila

Patterns of social participation among older adults and their association with self-rated health: the mediating role of activities of daily living

11 months ago
CONCLUSION: Activities of Daily Living mediates the relationship between social participation and Self-rated Health. Attention should be paid to the Activities of Daily Living of older adults, with particular attention to those living alone and those who are chronically ill, and to social resources to enhance the social participation of older persons.
Jiaxian Zhou