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Direct visualization of relativistic quantum scars in graphene quantum dots
MCM double hexamer loading visualized with human proteins
Multiple mechanisms for licensing human replication origins
Study design features increase replicability in brain-wide association studies
Soil microbiomes show consistent and predictable responses to extreme events
Digestive contents and food webs record the advent of dinosaur supremacy
Why build a muon collider: a three minute guide
Humble scientists earn more trust
Addendum: Accurate structure prediction of biomolecular interactions with AlphaFold 3
Transposable element 5mC methylation state of blood cells predicts age and disease
Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging
Customer reviews for Mystery Gadget 1.0, sorted in chronological order
Let the data talk: embrace exploratory research
How to stop plastic pollution: three strategies that actually work
How to thank your lab mates: eight ways to show gratitude at the end of year
Limits on foreign students are harming research, universities warn
Decoding senescence of aging single cells at the nexus of biomaterials, microfluidics, and spatial omics
Aging has profound effects on the body, most notably an increase in the prevalence of several diseases. An important aging hallmark is the presence of senescent cells that no longer multiply nor die off properly. Another characteristic is an altered immune system that fails to properly self-surveil. In this multi-player aging process, cellular senescence induces a change in the secretory phenotype, known as senescence-associated secretory phenotype (SASP), of many cells with the intention of...
Long-term exposure to excessive norepinephrine in the brain induces tau aggregation, neuronal death, and cognitive deficits in early tau transgenic mice
Alzheimer's disease (AD) is marked by the presence of intraneuronal neurofibrillary tangles (NFTs), which are primarily composed of hyperphosphorylated tau protein. The locus coeruleus (LC), the brain's main source of norepinephrine (NE), is one of the earliest regions to develop NFTs and experience neurodegeneration in AD. While LC-derived NE plays beneficial roles in cognition, emotion, locomotion, and the sleep-wake cycle, its impact on tau pathology is unclear. To explore this relationship,...
Expression of alpha smooth muscle actin decreases with ageing and increases upon lumen obstruction in mouse brain pericytes
Cerebral pericytes are mural cells covering brain microvessels, organized as ensheathing, mesh and thin-strand pericytes. These latter two, together called capillary pericytes, have low levels of alpha smooth muscle actin (α-SMA), regulating basal vascular tone and applying a slow influence on cerebral blood flow. Pericytes are subject to alterations in ageing which may be even more pronounced in age-related pathologies, including microinfarcts, which usually affect a large number of vessels in...
Decoding senescence of aging single cells at the nexus of biomaterials, microfluidics, and spatial omics
Aging has profound effects on the body, most notably an increase in the prevalence of several diseases. An important aging hallmark is the presence of senescent cells that no longer multiply nor die off properly. Another characteristic is an altered immune system that fails to properly self-surveil. In this multi-player aging process, cellular senescence induces a change in the secretory phenotype, known as senescence-associated secretory phenotype (SASP), of many cells with the intention of...