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Atomic locations and adsorbate interactions of Al single and pair sites in H-ZSM-5 zeolite
Science, Volume 387, Issue 6732, Page 388-393, January 2025.
Mechanically robust and stretchable organic solar cells plasticized by small-molecule acceptors
Science, Volume 387, Issue 6732, Page 381-387, January 2025.
A single gene orchestrates androgen variation underlying male mating morphs in ruffs
Science, Volume 387, Issue 6732, Page 406-412, January 2025.
Ductilization of 2.6-GPa alloys via short-range ordered interfaces and supranano precipitates
Science, Volume 387, Issue 6732, Page 401-406, January 2025.
Systematic identification of Y-chromosome gene functions in mouse spermatogenesis
Science, Volume 387, Issue 6732, Page 393-400, January 2025.
Photo-induced chirality in a nonchiral crystal
Science, Volume 387, Issue 6732, Page 431-436, January 2025.
Variable impacts of land-based climate mitigation on habitat area for vertebrate diversity
Science, Volume 387, Issue 6732, Page 420-425, January 2025.
Scientists as advocates
Science, Volume 387, Issue 6732, Page 368-368, January 2025.
In search of the female form
Science, Volume 387, Issue 6732, Page 367-367, January 2025.
Odd, fingerlike appendage helps this orchid reproduce
Strategy allows the plant to self-fertilize when pollinators aren’t present
Ancient humans evolved new blood types after leaving Africa
Genetic study also reveals blood groups modern humans acquired from Neanderthals
Will a new generation of water-splitting devices help green hydrogen replace fossil fuels?
Green hydrogen production will must increase 300-fold to help forestall dangerous climate change
News at a glance: Space X competitor, cancer institute leader, and the U.S. exit from Paris
The latest in science and policy
Personalized miniorgans could speed treatments for rare diseases
Method shrinks time for testing tailored RNA drugs from months to weeks
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation
Ergothioneine (ET), a dietary thione/thiol, is receiving growing attention for its possible benefits in healthy aging and metabolic resilience. Our study investigates ET's effects on healthspan in aged animals, revealing lifespan extension and enhanced mobility in Caenorhabditis elegans, accompanied by improved stress resistance and reduced age-associated biomarkers. In aged rats, ET administration enhances exercise endurance, muscle mass, and vascularization, concomitant with higher NAD^(+)...
The new science of menopause: these emerging therapies could change women's health
No abstract
X chromosome passed from mother to daughter influences brain ageing
No abstract
Depressive intensity, duration, and their associations with cognitive decline: a population-based study in Korea
Existing epidemiological studies have ignored the effect of depressive duration on cognitive decline despite the presence of biological cues and understudied the depression-cognition association in Asian countries in the context of increasing cognitive burden worldwide. We aimed to comprehensively characterize the effects of depressive duration and intensity on cognitive decline at the population level. A total of 6406 individuals from the Korean Longitudinal Study of Aging (KLoSA) from 2010 to...
Immune evasion through mitochondrial transfer in the tumour microenvironment
Cancer cells in the tumour microenvironment use various mechanisms to evade the immune system, particularly T cell attack¹. For example, metabolic reprogramming in the tumour microenvironment and mitochondrial dysfunction in tumour-infiltrating lymphocytes (TILs) impair antitumour immune responses^(2-4). However, detailed mechanisms of such processes remain unclear. Here we analyse clinical specimens and identify mitochondrial DNA (mtDNA) mutations in TILs that are shared with cancer cells....
Multiscale footprints reveal the organization of cis-regulatory elements
Cis-regulatory elements (CREs) control gene expression and are dynamic in their structure and function, reflecting changes in the composition of diverse effector proteins over time¹. However, methods for measuring the organization of effector proteins at CREs across the genome are limited, hampering efforts to connect CRE structure to their function in cell fate and disease. Here we developed PRINT, a computational method that identifies footprints of DNA-protein interactions from bulk and...