Aggregator

Science, Volume 387, Issue 6734, Page 559-559, February 2025.

Researchers facing “a lot of uncertainty, fear, and panic”

Mushroom corals roll, slide, and pulse to shuffle toward the light

Two decisions close chapter on controversies over origins of SARS-CoV-2

Chronic exposure to manganese (Mn) induces manganism and has been widely implicated as a contributing environmental factor to Parkinson's disease (PD), featuring notable overlaps between the two in motor symptoms and clinical hallmarks. Here, we developed an adult Drosophila model of Mn toxicity that recapitulated key parkinsonian features, spanning behavioral deficits, neuronal loss, and dysfunctions in lysosomes and mitochondria. Metabolomics analysis of the brain and body tissues of these...

In Alzheimer's disease (AD) research, the 5xFAD mouse model is commonly used as a heterozygote crossed with other genetic models to study AD pathology. We investigated whether the parental origin of the 5xFAD transgene affects plaque deposition. Using quantitative light-sheet microscopy, we found that paternal inheritance of the transgene led to a 2-fold higher plaque burden compared with maternal inheritance, a finding consistent across multiple 5xFAD colonies. This effect was not due to...

A metabolic switch enables hepatocytes in damaged livers to escape senescence and form tumors.

Telomeres are hypersensitive to the formation of the common oxidative lesion 8-oxoguanine (8oxoG), which impacts telomere stability and function. OGG1 and MUTYH glycosylases initiate base excision repair (BER) to remove 8oxoG or prevent mutation. Here, we show OGG1 loss or inhibition, or MUTYH loss, partially rescues telomeric 8oxoG-induced premature senescence and associated proinflammatory responses, while loss of both glycosylases causes a near complete rescue in human fibroblasts....

Precipitation is an important factor influencing the date of foliar senescence, which in turn affects carbon uptake of terrestrial ecosystems. However, the temporal patterns of precipitation frequency and its impact on foliar senescence date remain largely unknown. Using both long-term carbon flux data and satellite observations across the Northern Hemisphere, we show that, after excluding impacts from of temperature, radiation and total precipitation by partial correlation analysis, declining...

CONCLUSIONS: This study has brought to light the higher risk of anxiety among community-dwelling older adults compared to institutionalized older adults. Targeted interventions are, therefore emphasized to address the negative impact of anxiety for populations at higher risk.