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Targeting ATF6alpha Attenuates UVB-Induced Senescence and Improves Skin Homeostasis by Regulating IL8 Expression

10 months 4 weeks ago
Skin aging is influenced by both intrinsic and extrinsic factors, particularly UV radiation, and is characterized by an accumulation of senescent cells. Remarkably, exposure to UV can trigger senescence in different skin cell types, including dermal fibroblasts. However, the molecular mechanisms underlying UV-induced senescence and the impact of the related senescence-associated secretory phenotype (SASP) on the homeostasis of the overlying epidermis remain poorly understood. Here, we identified...
Joëlle Giroud

Benefits of onshoring forestry rely on science

10 months 4 weeks ago
Science, Volume 388, Issue 6746, Page 479-480, May 2025.
Matthew G. Betts, Jerry F. Franklin, Jacob J. Bukoski, Z. Burivalova, Emily E. Conklin, Thomas H. DeLuca, Amelia Fitch, Austin Himes, Rajat Panwar, Hannah Sachs, R. Alex Wiebe, and Gianluca Cerullo

In Science Journals

10 months 4 weeks ago
Science, Volume 388, Issue 6744, Page 265-267, April 2025.
Michael Funk, and Bianca Lopez, Jake S. Yeston, Marc S. Lavine, Jelena Stajic, Michael A. Funk, Leslie K. Ferrarelli, Courtney Malo, Keith T. Smith, Di Jiang, Yevgeniya Nusinovich, Corinne Simonti, Stella M. Hurtley, Peter Stern, and Christiana N. Fogg