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Receptor-binding specificity of a bovine influenza A virus
A. J. Eisfeld et al. reply
Mitochondrial metabolism sustains <i>DNMT3A</i>-R882-mutant clonal haematopoiesis
Reply to: Natively expressed AcrIII-1 does not function as an anti-CRISPR protein
What a trove of potato genomes reveals about the humble spud
Reframe perspectives on Alzheimer’s disease
Don’t believe the hype — quantum tech can’t yet solve real-world problems
You’re only human: a six-step strategy to surviving your PhD
Science on our sleeves: the research that inspires our tattoos
First global pandemic treaty agreed — without the US
Roses are red — but their ancestors were yellow
Print, melt, repeat: 3D-printing formula yields sturdy objects time after time
NIH’s 40% off budget, DOE cost cap blocked, and Seth Rogen defends science: Trump Tracker
Follow President Donald Trump’s impact on U.S. research and science globally
Claiming autism ‘epidemic,’ RFK Jr. describes NIH initiative to find environmental causes
Ignoring conclusions of new CDC report, HHS secretary promises “some” answers by September in research effort led by new NIH director
NSF halts grant awards while staff do second review
Action comes after DOGE team arrives at science agency
Global pandemic treaty finalized, without U.S., in ‘a victory for multilateralism’
Three years in the making, the accord aims to increase equity and avoid errors of the COVID-19 pandemic
Bizarre ‘Tatooine’ exoplanet orbits two failed stars at once
About 120 light-years from Earth, two brown dwarfs host a planet with a surprisingly sideways orbit
For economists, Trump’s trade war offers a rare opportunity to study tariffs
Chance to test trade theories might be “the only silver lining” in chaotic policies, one says
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins
Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microglia (iMG) could enable brain-wide and pathology-responsive delivery of therapeutic cargo, we utilized CRISPR gene editing to engineer iMG to express the Aβ-degrading enzyme neprilysin under control of the plaque-responsive promoter, CD9. To further determine whether increased engraftment enhances efficacy, we utilized a CSF1R-inhibitor resistance...
Diabetes affects AD through plasma Aβ40: A Mendelian randomization study
Amyloid and tau proteins are important proteins in the pathological changes of Alzheimer's disease (AD), while Aβ pathology and tau pathology are the most critical factors contributing to the development of AD. Some studies have shown that there is a causal relationship between AD and diabetes mellitus, but there are no studies showing a causal relationship between diabetic traits and AD biomarkers, so further exploration is needed. We first summarized and analyzed the currently published...