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Similarities and differences in the gene expression signatures of physiological age versus future lifespan
Across all taxa of life, individuals within a species exhibit variable lifespans. Differences in genotype or environment are not sufficient to explain this variance, as even isogenic Caenorhabditis elegans nematodes reared under uniform conditions show significant variability in lifespan. To investigate this phenomenon, we used lifespan-predictive biomarkers to isolate, at mid-adulthood, prospectively long- and short-lived individuals from an otherwise identical population. We selected two...
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Loose ends
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Mapping the microRNA landscape in the older adult brain and its genetic contribution to neuropsychiatric conditions
Wuhan lab samples hold no close relatives to virus behind COVID
Imperfect wound healing sets the stage for chronic diseases
Science, Volume 386, Issue 6726, December 2024.
Dissecting the hydrogen bond network of water: Charge transfer and nuclear quantum effects
Science, Volume 386, Issue 6726, December 2024.
Ecological erosion and expanding extinction risk of sharks and rays
Science, Volume 386, Issue 6726, December 2024.
Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs
Science, Volume 386, Issue 6726, December 2024.
Programming tissue-sensing T cells that deliver therapies to the brain
Science, Volume 386, Issue 6726, December 2024.
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Genetic risk factors for late-onset Alzheimer's disease drive senescence in female tauopathy mice
Carling et al. report that late-onset Alzheimer's disease (LOAD) risk alleles drive cellular senescence, a hallmark of aging, in a tau- and sex-dependent manner. Mechanistic insights into interactions among genetic risk, biological aging, and sex differences in LOAD are presented.
Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding beta-amyloidosis
No abstract