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Human-driven evolution of color in a stonefly mimic
Science, Volume 386, Issue 6720, Page 453-458, October 2024.
Pervasive sublethal effects of agrochemicals on insects at environmentally relevant concentrations
Science, Volume 386, Issue 6720, Page 446-453, October 2024.
A ubiquitous mobile genetic element changes the antagonistic weaponry of a human gut symbiont
Science, Volume 386, Issue 6720, Page 414-420, October 2024.
Spreading the word
Science, Volume 386, Issue 6720, Page 386-386, October 2024.
Imagination: A Manifesto
Science, Volume 386, Issue 6720, Page 387-387, October 2024.
Under the influence
Science, Volume 386, Issue 6720, Page 387-387, October 2024.
Detection of interstellar 1-cyanopyrene: A four-ring polycyclic aromatic hydrocarbon
Science, Volume 386, Issue 6723, Page 810-813, November 2024.
Predictions of groundwater PFAS occurrence at drinking water supply depths in the United States
Science, Volume 386, Issue 6723, Page 748-755, November 2024.
News at a glance: Biomed researchers using AI, whales eating plastic, and digital archive outage
The latest in science and policy
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Push for “data sovereignty” could reshape how scientists share information
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Research in mice and humans identifies a surprising role for these copy-and-paste snippets of DNA
Buoyed by ‘milestone’ clinical result, RNA editing is poised to treat diseases
Multiple approaches aim to counteract mutant genes by fixing the faulty RNA they produce
Medieval Silk Road metropolis unearthed in Uzbek mountains
Discovery challenges idea that ancient trade routes only linked lowland oases
Long-term lineage commitment in hematopoietic stem cell gene therapy
Hematopoietic Stem Cell (HSC) gene therapy (GT) may provide lifelong reconstitution of the hematopoietic system with gene-corrected cells¹. However, the effects of underlying genetic diseases, replication stress, and aging on hematopoietic reconstitution and lineage specification remain unclear. In this study, we analyzed hematopoietic reconstitution in 53 patients treated with lentiviral-HSC-GT for diverse conditions such as metachromatic leukodystrophy^(2,3) (MLD), Wiskott-Aldrich...
Parkinson's Disease
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Parkinson's Disease
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Parkinson's Disease. Reply
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EnteroBase in 2025: exploring the genomic epidemiology of bacterial pathogens
This paper presents an update on the content, accessibility and analytical tools of the EnteroBase platform for web-based pathogen genome analysis. EnteroBase provides manually curated databases of genome sequence data and associated metadata from currently >1.1 million bacterial isolates, more recently including Streptococcus spp. and Mycobacterium tuberculosis, in addition to Salmonella,Escherichia/Shigella,Clostridioides,Vibrio,Helicobacter,YersiniaandMoraxella. We have implemented the...
The dynamic crosslinking between gut microbiota and inflammation during aging: reviewing the nutritional and hormetic approaches against dysbiosis and inflammaging
The early-life gut microbiota (GM) is increasingly recognized for its contributions to human health and disease over time. Microbiota composition, influenced by factors like race, geography, lifestyle, and individual differences, is subject to change. The GM serves dual roles, defending against pathogens and shaping the host immune system. Disruptions in microbial composition can lead to immune dysregulation, impacting defense mechanisms. Additionally, GM aids digestion, releasing nutrients and...
Subjective well-being across the life course among non-industrialized populations
Subjective well-being (SWB) is often described as being U-shaped over adulthood, declining to a midlife slump and then improving thereafter. Improved SWB in later adulthood has been considered a paradox given age-related declines in health and social losses. While SWB has mostly been studied in high-income countries, it remains largely unexplored in rural subsistence populations lacking formal institutions that reliably promote social welfare. Here, we evaluate the age profile of SWB among three...