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Transcriptomic neuron types vary topographically in function and morphology
Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy
Learning produces an orthogonalized state machine in the hippocampus
Observation of an ultra-high-energy cosmic neutrino with KM3NeT
Gourmet cockatoos like to fancy up their food
Cheap blood test detects pancreatic cancer before it spreads
Observation of Plastic Ice VII by Quasi-Elastic Neutron Scattering
σ-Bond insertion reactions of two strained diradicaloids
Soluble cerebral Aβ protofibrils link Aβ plaque pathology to changes in CSF Aβ<sub>42</sub>/Aβ<sub>40</sub> ratios, neurofilament light and tau in Alzheimer’s disease model mice
Oligodendrocyte ankyrin G in aging
Dear Leader
Why is mathematics education failing some of the world’s most talented children?
Dozens of new obesity drugs are coming: these are the ones to watch
Transylvanian diaries reveal centuries-old climate extremes
Canceling data collections could imperil efforts to improve U.S. education, a former Trump appointee warns
Ex-head of National Center for Education Statistics describes impact of massive halt to survey research
Jupiter’s biggest moons may have emerged from the shadows
Jovian satellites may have formed in cold spots in the disk of gas and dust surrounding the infant planet
Human and mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome
Murine models of Alzheimer's disease (AD) are crucial for elucidating disease mechanisms but have limitations in fully representing AD molecular complexities. Here we present the comprehensive, age-dependent brain proteome and phosphoproteome across multiple mouse models of amyloidosis. We identified shared pathways by integrating with human metadata and prioritized components by multi-omics analysis. Collectively, two commonly used models (5xFAD and APP-KI) replicate 30% of the human protein...
Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies
Despite advances in treatment, the prognosis for patients with pulmonary arterial hypertension (PAH) remains dismal, highlighting the need for further therapeutic advances. By using RNA sequencing on pulmonary artery smooth muscle cells (PASMCs), functional enrichment, and connectivity map analyses, we identify Aurora kinase B (AURKB) as a candidate therapeutic target. We show that AURKB inhibition blocks cell cycle progression and reverses the gene signature of PAH-PASMCs. We also report that...
Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca(2+) handling across the adult lifespan in men
Aging-related muscle atrophy and weakness contribute to loss of mobility, falls, and disability. Mitochondrial dysfunction is widely considered a key contributing mechanism to muscle aging. However, mounting evidence positions physical activity as a confounding factor, making unclear whether muscle mitochondria accumulate bona fide defects with aging. To disentangle aging from physical activity-related mitochondrial adaptations, we functionally profiled skeletal muscle mitochondria in 51...
Rpl12 is a conserved ribophagy receptor
Ribophagy is a selective autophagic process that regulates ribosome turnover. Although NUFIP1 has been identified as a mammalian receptor for ribophagy, its homologues do not exist in yeast and nematodes. Here we demonstrate that Rpl12, a ribosomal large subunit protein, functions as a conserved ribophagy receptor in multiple organisms. Disruption of Rpl12-Atg8s binding leads to significant accumulation of ribosomal proteins and rRNA, while Atg1-mediated Rpl12 phosphorylation enhances its...