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Brain malformations and seizures by impaired chaperonin function of TRiC
Science, Volume 386, Issue 6721, Page 516-525, November 2024.
Cation reactivity inhibits perovskite degradation in efficient and stable solar modules
Science, Volume 386, Issue 6721, Page 531-538, November 2024.
Shrub cover declined as Indigenous populations expanded across southeast Australia
Science, Volume 386, Issue 6721, Page 567-573, November 2024.
Cooperative adsorbate binding catalyzes high-temperature hydrogen oxidation on palladium
Science, Volume 386, Issue 6721, Page 511-516, November 2024.
From baby blues to depression
Science, Volume 386, Issue 6721, Page 500-500, November 2024.
Keeping outbreaks at bay
Science, Volume 386, Issue 6721, Page 499-499, November 2024.
At global biodiversity summit, AI starts to make a splash
Automated tools could help nations reach conservation goals, scientists say
NASA instrument to study the mysterious origins of the solar wind
By creating artificial eclipses, CODEX will track bursts of charged particles that stream from the Sun
News at a glance: Reexamining Arecibo’s collapse, measuring plankton, and honoring Henrietta Lacks
The latest in science and policy
Why are parrots so colorful? Study points to simple chemical tweak
Genetic and chemical analyses reveal secret to birds’ brilliant plumage
Britain’s postwar sugar craze confirms harms of sweet diets in early life
End of sugar rationing boosted diabetes, hypertension rates years later
Can people be ‘inoculated’ against misinformation?
A strategy pioneered during the Cold War may prevent people from believing and sharing online falsehoods
As U.S. election looms, this ‘rumor researcher’ tracks—and combats—falsehoods in real time
Kate Starbird’s work at the Center for an Informed Public has made her the target of political attacks
Reconsider use of race in biomedical research, panel urges
National Academies report is latest to address concerns about how scientists rely on racial and ethnic categories
Lab-created ‘protocells’ provide clues to how life arose
Simple ingredients could have formed first cell membranes
Alcohol consumption confers lasting impacts on prefrontal cortical neuron intrinsic excitability and spontaneous neurotransmitter signaling in the aging brain in mice
Both alcohol use disorder (AUD) and cognitive decline include disruption in the balance of excitation and inhibition in the cortex, but the potential role of alcohol use on excitation and inhibition on the aging brain is unclear. We examined the effect of moderate voluntary binge alcohol consumption on the aged, pre-disease neuronal environment by measuring intrinsic excitability and spontaneous neurotransmission on prefrontal cortical pyramidal (excitatory, glutamatergic) and non-pyramidal...
Application of frailty screening instruments for older people in Sub-Saharan Africa: A scoping review
CONCLUSION: Considering the impact of frailty on the health and wellbeing of older people, researchers must consider developing and using frailty screening instruments that assess domains that are pertinent to the health and wellbeing of older people in Sub-Saharan Africa.
Inhibition of an Alzheimer's disease-associated form of necroptosis rescues neuronal death in mouse models
Necroptosis is a regulated form of cell death that has been observed in Alzheimer's disease (AD) along with the classical pathological hallmark lesions of amyloid plaques and Tau neurofibrillary tangles. To understand the neurodegenerative process in AD, we studied the role of necroptosis in mouse models and primary mouse neurons. Using immunohistochemistry, we demonstrated activated necroptosis-related proteins in transgenic mice developing Tau pathology and in primary neurons from amyloid...
Single-cell transcriptomic and proteomic analysis of Parkinson's disease brains
Parkinson's disease (PD) is a prevalent neurodegenerative disorder, and recent evidence suggests that pathogenesis may be in part mediated by inflammatory processes, the molecular and cellular architectures of which are largely unknown. To identify and characterize selectively vulnerable brain cell populations in PD, we performed single-nucleus transcriptomics and unbiased proteomics to profile the prefrontal cortex from postmortem human brains of six individuals with late-stage PD and six...
Measurement of α-synuclein as protein cargo in plasma extracellular vesicles
Extracellular vesicles (EVs) are released by all cells and hold great promise as a class of biomarkers. This promise has led to increased interest in measuring EV proteins from both total EVs as well as brain-derived EVs in plasma. However, measuring cargo proteins in EVs has been challenging because EVs are present at low levels, and EV isolation methods are imperfect at separating EVs from free proteins. Thus, knowing whether a protein measured after EV isolation is truly inside EVs is...