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Photonic axion insulator

10 months ago
Science, Volume 387, Issue 6730, Page 162-166, January 2025.
Gui-Geng Liu, Subhaskar Mandal, Xiang Xi, Qiang Wang, Chiara Devescovi, Antonio Morales-Pérez, Ziyao Wang, Linyun Yang, Rimi Banerjee, Yang Long, Yan Meng, Peiheng Zhou, Zhen Gao, Yidong Chong, Aitzol García-Etxarri, Maia G. Vergniory, Baile Zhang






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Are oligodendrocytes bystanders or drivers of Parkinson's disease pathology?

10 months ago
The major pathological feature of Parkinson 's disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons in the substantia nigra, a part of the midbrain. Despite decades of research, the molecular mechanisms of the origin of the disease remain unknown. While the disease was initially viewed as a purely neuronal disorder, results from single-cell transcriptomics have suggested that oligodendrocytes may...
José María Salazar Campos

Stereo-seq of the prefrontal cortex in aging and Alzheimer's disease

10 months ago
Aging increases the risk for Alzheimer's disease (AD), driving pathological changes like amyloid-β (Aβ) buildup, inflammation, and oxidative stress, especially in the prefrontal cortex (PFC). We present the first subcellular-resolution spatial transcriptome atlas of the human prefrontal cortex (PFC), generated with Stereo-seq from six male AD cases at varying neuropathological stages and six age-matched male controls. Our analyses revealed distinct transcriptional alterations across PFC layers,...
Yun Gong

Heritable polygenic editing: the next frontier in genomic medicine?

10 months ago
Polygenic genome editing in human embryos and germ cells is predicted to become feasible in the next three decades. Several recent books and academic papers have outlined the ethical concerns raised by germline genome editing and the opportunities that it may present^(1-3). To date, no attempts have been made to predict the consequences of altering specific variants associated with polygenic diseases. In this Analysis, we show that polygenic genome editing could theoretically yield extreme...
Peter M Visscher

Modulating mTOR-dependent astrocyte substate transitions to alleviate neurodegeneration

10 months ago
Traditional approaches to studying astrocyte heterogeneity have mostly focused on analyzing static properties, failing to identify whether subtypes represent intermediate or final states of reactive astrocytes. Here we show that previously proposed neuroprotective and neurotoxic astrocytes are transitional states rather than distinct subtypes, as revealed through time-series multiomic sequencing. Neuroprotective astrocytes are an intermediate state of the transition from a nonreactive to a...
Liansheng Zhang

EBP1 potentiates amyloid β pathology by regulating γ-secretase

10 months ago
The abnormal deposition of amyloid β (Aβ), produced by proteolytic cleavage events of amyloid precursor protein involving the protease γ-secretase and subsequent polymerization into amyloid plaques, plays a key role in the neuropathology of Alzheimer's disease (AD). Here we show that ErbB3 binding protein 1 (EBP1)/proliferation-associated 2G4 (PA2G4) interacts with presenilin, a catalytic subunit of γ-secretase, inhibiting Aβ production. Mice lacking forebrain Ebp1/Pa2g4 recapitulate the...
Byeong-Seong Kim