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Age-associated metabolic and epigenetic barriers during direct reprogramming of mouse fibroblasts into induced cardiomyocytes
Heart disease is the leading cause of mortality in developed countries, and novel regenerative procedures are warranted. Direct cardiac conversion (DCC) of adult fibroblasts can create induced cardiomyocytes (iCMs) for gene and cell-based heart therapy, and in addition to holding great promise, still lacks effectiveness as metabolic and age-associated barriers remain elusive. Here, by employing MGT (Mef2c, Gata4, Tbx5) transduction of mouse embryonic fibroblasts (MEFs) and adult (dermal and...
Exploring the perceptions and experiences of older people on the use of digital technologies during the COVID-19 pandemic: a qualitative study
CONCLUSION: Digital technologies offered a lifeline during COVID-19 to maintain social contact and their use was found acceptable by older people. Digital platforms such as Zoom can be further employed to conduct remotely delivered interventions with the aim to increase uptake of social and physical activity interventions within this population.
Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model
Impaired sleep is a common aspect of aging and often precedes the onset of Alzheimer's disease. Here, we compare the effects of sleep deprivation in young wild-type mice and their APP/PS1 littermates, a murine model of Alzheimer's disease. After 7 h of sleep deprivation, both genotypes exhibit an increase in EEG slow-wave activity. However, only the wild-type mice demonstrate an increase in the power of infraslow norepinephrine oscillations, which are characteristic of healthy non-rapid eye...
The immune landscape of murine skeletal muscle regeneration and aging
Age-related alterations in the immune system are starting to emerge as key contributors to impairments found in aged organs. A decline in regenerative capacity is a hallmark of tissue aging; however, the contribution of immune aging to regenerative failure is just starting to be explored. Here, we apply a strategy combining single-cell RNA sequencing with flow cytometry, histological analysis, and functional assays to perform a complete analysis of the immune environment of the aged regenerating...
Daily briefing: Big tomatoes get sweeter thanks to CRISPR editing
Resistance to crucial malaria drug detected in severely ill kids in Africa
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
The metaphors of artificial intelligence
Science, Volume 386, Issue 6723, November 2024.
US trust in scientists plunged during the pandemic — but it’s starting to recover
Geothermal power is vying to be a major player in the world’s clean-energy future
Can robotic lab assistants speed up your work?
Huge carnivorous ‘terror bird’ rivalled the giant panda in size
Engineered receptors for soluble cellular communication and disease sensing
Reactivation of senescence-associated endogenous retroviruses by ATF3 drives interferon signaling in aging
Why AI-generated recommendation letters sell applicants short
Pathways to reduce global plastic waste mismanagement and greenhouse gas emissions by 2050
Science, Volume 386, Issue 6726, Page 1168-1173, December 2024.
In Science Journals
Science, Volume 386, Issue 6723, Page 740-742, November 2024.
To target, to escape, perchance to cure: Borrowing a page from cancer’s playbook, scientists learn to evade their own therapies
Science, Volume 386, Issue 6723, Page 739-739, November 2024.
How to build a human: Piecing together the body’s cellular puzzle
Science, Volume 386, Issue 6723, Page 739-739, November 2024.
Digging below the surface: Hidden risks for ground-nesting bees
Science, Volume 386, Issue 6723, Page 739-739, November 2024.