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How much ultra-processed food do you eat? Blood and urine record it
I told AI to make me a protein. Here’s what it came up with
Does lightning make trees swish?
One-carbon homologation of alkenes
Activation of AMPK by GLP-1R agonists mitigates Alzheimer-related phenotypes in transgenic mice
Large-scale plasma proteomic profiling unveils diagnostic biomarkers and pathways for Alzheimer’s disease
GLP-1R agonists protect against Alzheimer’s disease by rewiring energy regulation
Richard Garwin obituary: designer of the hydrogen bomb who advocated for arms control
Philanthropic funders: team up to jump-start innovative science
Who were the ancient Denisovans? Fossils reveal secrets about the mysterious humans
How ‘organized looting and plunder’ drove Britain’s second scientific revolution
Don’t forget the lessons of the McCarthy era
Data resources must be protected from political interference
AI-generated literature reviews threaten scientific progress
AI bots threaten online scientific infrastructure
Author Correction: Earth’s ambipolar electrostatic field and its role in ion escape to space
Research may be increasingly incremental—but studies making lasting paradigm shifts are on the rise
New metric identifying “persistently disruptive” papers offers a “bright spot” amid signs of declining innovation
Xanthones as neuroprotective agents: A comprehensive review of their role in the prevention and treatment of neurodegenerative diseases
Over the recent years, numerous research efforts have been focused toward xanthones, a class of heterocyclic compounds characterized by a three-ring core structure and a diverse range of biological activities. Despite extensive studies, no xanthone-based molecule has successfully progressed through clinical trials to reach pharmaceutical applications. Xanthones belong to the class of secondary metabolites that exist naturally, found in various plant species, and their structural diversity has...
Sex-specific insights into drug-induced lifespan extension and weight loss in mice
The DrugAge database serves as a comprehensive resource for studying compounds that increase lifespan in model organisms. In the latest version of DrugAge, we implemented multiple updates, predominantly focusing on mouse studies to enhance data accuracy and consistency. Key improvements include re-recording of mouse data from original sources, standardization of drug dosages to parts per million, and recording of administration routes, treatment initiation ages, and lifespans of controls. The...
Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis
With increased age, the liver becomes more vulnerable to metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis. Deciphering the complex interplay between aging, the emergence of senescent cells in the liver and MASH fibrosis is critical for developing treatments. Here we report an epigenetic mechanism that links liver aging to MASH fibrosis. We find that upregulation of the chromatin remodeler BAZ2B in a subpopulation of hepatocytes (HEPs) is linked to MASH pathology in patients....