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Cardiovascular and infectious diseases both feature among the leading causes of death among men and women in the world. The pathophysiological pathways of infection and cardiovascular disease intersect, and there is a bidirectional relationship between the two. Vaccines are available for the most common infectious diseases affecting older adults, such as influenza, pertussis, pneumococcal disease, herpes zoster, COVID and respiratory syncytial virus (RSV). In many countries, these vaccines are...

Active Ageing (AA) involves maintaining engagement in physical, social, and mental activities in older adulthood, reflecting societal values and political agendas. Despite various measurement tools, there is no universal standard. The University of Jyväskylä Active Ageing Scale (UJACAS) is increasingly used in Europe but faces inconsistencies from varying response scales across versions. This perspective paper examines these discrepancies and proposes a refined model for AA measurement,...

CONCLUSION: The findings of this study provide further evidence for the genetic correlation between gut microbiota and accelerated aging as well as frailty, enhancing the understanding of the role of gut microbiota in aging-related processes. However, the underlying mechanisms and potential clinical applications require further investigation before any targeted interventions can be developed.

CONCLUSIONS: This study shows that moderate and severe food insecurity are associated with an increase in the rates of sarcopenia and severe sarcopenia over time.

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CONCLUSIONS: Our study provides new insights into the roles of m⁶A modification and its crosstalk with histone modification in 5' UTRs, shedding light on the mechanism of m⁶A-mediated gene expression regulation.

Cognitive function in aging is heterogeneous: while some older individuals develop significant impairments and dementia, others remain resilient and retain cognitive function throughout their lifespan. The molecular mechanisms that underlie these divergent cognitive trajectories, however, remain largely unresolved. Here, we utilized a high-resolution home-cage-based cognitive testing paradigm to delineate mechanisms that contribute to age-related cognitive heterogeneity. We cognitively...

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Science, Volume 387, Issue 6739, Page 1159-1161, March 2025.

Science, Volume 387, Issue 6739, Page 1153-1156, March 2025.

Science, Volume 387, Issue 6739, Page 1127-1127, March 2025.