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Good COPs, bad COPs: science struggles in a year of environmental summits
Can AI-generated podcasts boost science engagement?
<b>CRISPR genome-editing grows up: advanced therapies head for the clinic</b>
Science in 2025: the events to watch for in the coming year
Northern India and Pakistan are yet again engulfed in a haze of pollution — but a lasting solution is possible
‘The next five years will be a crucial time’: meet the analyst shaping space policy
To spur climate action, educators must get personal
A message of peace to Jupiter’s moon from actually all of humankind
Animals in sticky situations
Facilitate the move of academia from X to Bluesky
If anyone’s reading this Correspondence in 1,130 years’ time, please let us know
How climate change is changing calendars — and what to do about it
Publisher Correction: Mapping the ionosphere with millions of phones
Shoddy commentaries—a quick and dirty route to higher impact numbers—are on the rise
AI-generated content floods literature with poor-quality publications, casts doubt on metrics, Science and Retraction Watch investigation finds
Advocate for girls in science can now make her pitch in Congress
Electrical engineer Luz Rivas, a Democrat from California, has helped remove barriers for other Latinas in STEM
Could psychedelic drugs improve the mental health of autistic people?
A brace of new studies probes benefits and risks for an understudied group
Young double-star system discovered near our Galaxy’s giant black hole
Surprising find could force rethink of astrophysics at Milky Way’s center
Watch thirsty rattlesnakes drink from the scales of other snakes
Behavior may keep the reptiles alive in arid climates
Immune mechanisms and shared immune targets in neurodegenerative diseases
The immune system plays a major part in neurodegenerative diseases. In some, such as multiple sclerosis, it is the primary driver of the disease. In others, such as Alzheimer disease, amyotrophic lateral sclerosis and Parkinson disease, it has an amplifying role. Immunotherapeutic approaches that target the adaptive and innate immune systems are being explored for the treatment of almost all neurological diseases, and the targets and approaches are often common across diseases. Microglia are the...
Increased mitochondrial mutation heteroplasmy induces aging phenotypes in pluripotent stem cells and their differentiated progeny
The mitochondrial genome (mtDNA) is an important source of inherited extranuclear variation. Clonal increases in mtDNA mutation heteroplasmy have been implicated in aging and disease, although the impact of this shift on cell function is challenging to assess. Reprogramming to pluripotency affects mtDNA mutation heteroplasmy. We reprogrammed three human fibroblast lines with known heteroplasmy for deleterious mtDNA point or deletion mutations. Quantification of mutation heteroplasmy in the...