Aggregator
PCBP2 as an intrinsic agi ng factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis
CONCLUSIONS: This study initially elucidates that PCBP2 as an intrinsic aging factor regulates the replicative senescence of hBMSCs through the ROS-FGF2 signaling axis.
A Single-Cell Transcriptome Atlas Characterizes the Immune Landscape of Human Testes During Aging
Aging disrupts immune regulation, affecting tissue function and increasing vulnerability to various diseases. However, the effects of aging on immune cells within human testes are not well understood. In this study, we utilized single-cell RNA sequencing to profile immune cells from 33 human testis samples from individuals aged 21 to 69. Our analysis revealed key immune cell types, including CD8^(+) T cells, monocytes, cDC2 cells, and various macrophage subtypes within the testes. We observed an...
Prediction of hearing aid cognitive outcomes in age-related hearing loss
Although the phenomena underlying cognitive decline and dementia are complex, there is growing evidence suggesting that degraded sensory inputs caused by age-related hearing loss may play a central role in accelerating cognitive decline in older individuals. Further supporting this notion is evidence that hearing augmentation with hearing aids can mitigate hearing loss-related cognitive impairments. Despite this evidence, few studies have attempted to investigate hearing aid efficacy with a...
Daily briefing: This key protein could be responsible for brain ageing
‘Scientists will not be silenced’: thousands protest Trump research cuts
Who’s likely to wake up from a coma? Brainwaves provide a clue
The surprising culprit for the loss of huge swathes of tropical forest
A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan
Cold is hot for slowing aging
Accelerating the promise of geroscience through The Academy of Health & Lifespan Research
How a PhD student’s lab size affects their chance of future academic success
AI tools are spotting errors in research papers: inside a growing movement
Microsoft quantum computing ‘breakthrough’ faces fresh challenge
‘I was told to toughen up’: is academia getting resilience all wrong?
Rock hunters, tree huggers and taxi drivers: Books in brief
Author Correction: Warming and cooling catalyse widespread temporal turnover in biodiversity
Ice-hunting Moon lander runs into trouble ― leaving scientists in suspense
A subcellular map of translational machinery composition and regulation at the single-molecule level
Science, Volume 387, Issue 6738, March 2025.
Historic manioc genomes illuminate maintenance of diversity under long-lived clonal cultivation
Science, Volume 387, Issue 6738, March 2025.
G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation
Science, Volume 387, Issue 6738, March 2025.