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Bottom-up reconstruction of functional death fold signalosomes reveals a requirement for polymer stability and avidity
Science, Volume 388, Issue 6745, Page 415-422, April 2025.
Observation of generalized t-J spin dynamics with tunable dipolar interactions
Science, Volume 388, Issue 6745, Page 381-386, April 2025.
Microlensing events indicate that super-Earth exoplanets are common in Jupiter-like orbits
Science, Volume 388, Issue 6745, Page 400-404, April 2025.
The variable nature of sex
Science, Volume 388, Issue 6745, Page 368-368, April 2025.
Science of death
Science, Volume 388, Issue 6745, Page 369-369, April 2025.
Missed connections
Science, Volume 388, Issue 6745, Page 369-369, April 2025.
Researcher of 1918 flu virus takes over NIAID
Jeffery Taubenberger becomes acting director of NIH’s second largest institute
Exclusive: NSF director to resign amid grant terminations, job cuts, and controversy
“I have done all I can,” says Sethuraman Panchanathan, a Trump appointee who has led agency since 2020
In Vietnam, the health effects of Agent Orange remain uncertain 50 years later
Researchers struggle to document the long-term impact of massive herbicide spraying
News at a glance: claimed exoplanet life signs, an advance in ultracold microscopy, and slashed funds for U.S. environmental research
The latest in science and policy
A notorious performance-enhancing hormone helps tumors hide from the immune system
Blocking erythropoietin’s effects on macrophages fights cancer in mice
Vietnam War’s survivors shed light on the long-term tolls of military conflict
Researchers are working with people who lived through the war as teenagers to understand conflict’s long-term tolls
In China, trade war with U.S. taking a toll on research labs
Scientists face higher prices and import bans on equipment and supplies
Massive pea study solves last genetic riddles of famed friar
DNA sequencing reveals basis of traits studied by Gregor Mendel—and gives breeders new ways to improve the crop
Most Phoenicians did not come from the land of Canaan, challenging historical assumptions
Culture with biblical roots spread across the ancient world, but its people did not
How much climate damage do polluters actually cause? New method comes up with price tag
Approach might help plaintiffs win compensation from top emitters
Defining essential charged residues in fibril formation of a lysosomal derived N-terminal α-synuclein truncation
N- and C-terminal α-synuclein (α-syn) truncations are prevalent in Parkinson's disease. Effects of the N- and C-terminal residues on α-syn aggregation and fibril propagation are distinct, where the N-terminus dictates fibril structure. Here, the majority of α-syn truncations are assigned by intact mass spectrometry to lysosomal activity. To delineate essential charged residues in fibril formation, we selected an N-terminal truncation (66-140) that is generated solely from soluble α-syn by...
LinAge2: providing actionable insights and benchmarking with epigenetic clocks
Biological aging is marked by a decline in resilience at the cellular and systemic levels, driving an exponential increase in mortality risk. Here, we evaluate several clinical and epigenetic clocks for their ability to predict mortality, demonstrating that clocks trained on survival and functional aging outperform those trained on chronological age. We present an enhanced clinical clock that predicts mortality more accurately and provides actionable insights for guiding personalized...
Loss of intracellular ATP affects axoplasmic viscosity and pathological protein aggregation in mammalian neurons
Neurodegenerative diseases display synaptic deficits, mitochondrial defects, and protein aggregation. We show that intracellular adenosine triphosphate (ATP) regulates axoplasmic viscosity and protein aggregation in mammalian neurons. Decreased intracellular ATP upon mitochondrial inhibition leads to axoterminal cytosol, synaptic vesicles, and active zone component condensation, modulating the functional organization of mouse glutamatergic synapses. Proteins involved in the pathogenesis of...
Genetics- and age-driven neuroimmune and disc changes underscore herniation susceptibility and pain-associated behaviors in SM/J mice
There are no appropriate mouse models to study the pathophysiology of spontaneous disc herniations in a wild-type setting. SM/J mice, a poor healer inbred strain, presented a high incidence of age-associated lumbar disc herniations with neurovascular innervations. Transcriptomic comparisons of the SM/J annulus fibrosus with human tissues showed shared pathways related to immune cell activation and inflammation. Notably, aged SM/J mice showed increased pain sensitization and neuroinflammation...