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Global tracking of marine megafauna space use reveals how to achieve conservation targets
Science, Volume 388, Issue 6751, Page 1086-1097, June 2025.
Integrated carbon and nitrogen management for cost-effective environmental policies in China
Science, Volume 388, Issue 6751, Page 1098-1103, June 2025.
Interface morphogenesis with a deformable secondary phase in solid-state lithium batteries
Science, Volume 388, Issue 6751, Page 1062-1068, June 2025.
Passive cooling paint enabled by rational design of thermal-optical and mass transfer properties
Science, Volume 388, Issue 6751, Page 1044-1049, June 2025.
Archaeological evidence of intensive indigenous farming in Michigan’s Upper Peninsula, USA
Science, Volume 388, Issue 6751, Page 1082-1085, June 2025.
In-insect synthesis of oxygen-doped molecular nanocarbons
Science, Volume 388, Issue 6751, Page 1055-1061, June 2025.
Dehorning reduces rhino poaching
Science, Volume 388, Issue 6751, Page 1075-1081, June 2025.
Direct measurement of the quantum metric tensor in solids
Science, Volume 388, Issue 6751, Page 1050-1054, June 2025.
Oxygen intrusions sustain aerobic nitrite-oxidizing bacteria in anoxic marine zones
Science, Volume 388, Issue 6751, Page 1069-1074, June 2025.
Values remain a mystery to many economists
Science, Volume 388, Issue 6751, Page 1032-1032, June 2025.
In defense of silly science
Science, Volume 388, Issue 6751, Page 1031-1031, June 2025.
Strangling intellectual independence
Science, Volume 388, Issue 6752, Page 1115-1115, June 2025.
Local predictions of climate change are hazy. But cities need answers fast
Scientists are figuring out where “downscaled” climate models struggle—and how they can be improved
600 years before Europeans arrived, Great Lakes farmers transformed the land
Despite poor conditions, Indigenous growers used innovative techniques to grow large crops of corn, beans, and squash
African countries fall far short of mpox vaccination targets
Continent faces a shortage of doses and distribution challenges
Association between near functional visual acuity and physical function in community-dwelling older adults: a cross-sectional study : Keio university global research Institute baseline survey
CONCLUSIONS: The study showed an association between quantitatively assessed visual and physical functions in community-dwelling older adults living in Japan. Thus, the findings indicate that maintaining and enhancing grip strength and visual function in older adults may be an important factor in leading a healthy and fulfilling life.
Reevaluating Leucine's effects on Alzheimer's disease: evidence of potential benefits overlooked
No abstract
Intracellular accumulation of amyloid-ss is a marker of selective neuronal vulnerability in Alzheimer's disease
Defining how amyloid-β and pTau together lead to neurodegeneration is fundamental to understanding Alzheimer's disease (AD). We used imaging mass cytometry to identify neocortical neuronal subtypes lost with AD in post-mortem brain middle temporal gyri from non-diseased and AD donors. Here we showed that L5,6 RORB^(+)FOXP2^(+) and L3,5,6 GAD1^(+)FOXP2^(+) neurons, which accumulate amyloid-β intracellularly from early Braak stages, are selectively vulnerable to degeneration in AD, while L3...
An AI-assisted fluorescence microscopic system for screening mitophagy inducers by simultaneous analysis of mitophagic intermediates
Mitophagy, the selective autophagic elimination of mitochondria, is essential for maintaining mitochondrial quality and cell homeostasis. Impairment of mitophagy flux, a process involving multiple sequential intermediates, is implicated in the onset of numerous neurodegenerative diseases. Screening mitophagy inducers, particularly understanding their impact on mitophagic intermediates, is crucial for neurodegenerative disease treatment. However, existing techniques do not allow simultaneous...
Stem cell therapies advance in Parkinson's disease and beyond
No abstract