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Creatine and cellular senescence: from molecular pathways to populational health

8 months ago
Emerging evidence suggests that creatine, a naturally occurring amino acid derivative and conditionally essential nutrient, may modulate cellular senescence through mechanisms such as enhancing cellular energy homeostasis, mitigating oxidative stress, and influencing key signaling pathways implicated in aging processes. This review critically evaluates the current body of research, highlights existing gaps in the mechanistic understanding, and emphasizes the importance of targeted studies to...
Sergej M Ostojic

Changes in end-of-life care models among Chinese older adults, 1998-2018: an age-period-cohort analysis

8 months ago
CONCLUSIONS: The changes in end-of-life care models for Chinese older adults are influenced by both age and period effects. The sustainability of the child-centered care model, influenced by filial piety culture, is facing challenges, as the responsibility for end-of-life care has gradually expanded from children to a broader circle of caregivers. Future efforts should focus on developing a care model based on family caregiving, supplemented by formal care services. Additionally, older women and...
Xiaoyan Hei

Decoding the Enigmatic Link Between Sensory Impairment and Organic Mental Disorders: Insights From Biological Aging and Social Support in a Population Cohort Study

8 months ago
CONCLUSIONS AND IMPLICATIONS: Sensory impairments are associated with an increased risk of organic mental disorders, potentially partly mediated by accelerated biological aging, with social support demonstrating a significant moderating effect. The gradient of risk across impairment types and the substantial potential mediating effect of biological age acceleration are consistent with multiple pathways linking sensory and cognitive health. These findings indicate that comprehensive interventions...
Ce Liu