Aggregator

INTRODUCTION: Older age is associated with alterations in executive functioning (EF). Age-related alterations in the integrity of structural brain networks may contribute to EF decline, with potential consequences for independent living. Graph theory provides powerful metrics to examine the brain's structural connectome, but few studies have investigated the relationship of EF and structural brain networks, as described by graph-theoretical measures, in older adults. We aimed to investigate the...

CONCLUSION: Peer programs have continued to leverage hybrid communication and expanded health and city partnerships to meet the needs of socially isolated older adults. Results further suggest their potential to be integrated into future public health emergency responses.

DNA methylation (DNAm) algorithms have been developed to assess biological aging and its association with cancer. Despite their potential, direct comparisons to identify the most accurate algorithm for predicting cancer risk and mortality remain limited. The study population (n = 2532) consisted of adults aged 50 years and older from the National Health and Nutrition Examination Survey, with 17-year follow-up mortality data. Twelve DNAm algorithms were evaluated using Illumina EPIC BeadChip...

This study is the first to investigate the anti-aging effects of the newly synthesized compound, 3,4,5-tri-feruloylquinic acid (TFQA), in vivo using the senescence-accelerated mouse prone 8 (SAMP8) model, through integrated whole-transcriptomic and biochemical analyses. Oral administration of TFQA (1 mg/kg body weight) for 37 days led to significant cognitive improvements, as demonstrated by enhanced performance in the Morris water maze (MWM) test, including reduced escape latency and increased...

As Piers Forster steps down as chair of the influential Climate Change Committee, he chats with Science about his role in guiding the country toward decarbonization