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Two-year probe led by Republicans faults agencies for pandemic response, as Democrats on panel challenge final report’s findings on SARS-CoV-2’s origin

Benchmark shows humans can still top machines—but for how much longer?

Researchers probe immediate and long-term threats at two of continent’s biggest magmatic tinderboxes

Deal allows scholars to read paywalled articles for free and will cover open-access fees

Fine-grained imaging of mouse brain cells suggests “pearling” of axons that researchers think may help with signaling

Portable, low-field magnetic resonance imaging (LF-MRI) of the brain may facilitate point-of-care assessment of patients with Alzheimer's disease (AD) in settings where conventional MRI cannot. However, image quality is limited by a lower signal-to-noise ratio. Here, we optimize LF-MRI acquisition and develop a freely available machine learning pipeline to quantify brain morphometry and white matter hyperintensities (WMH). We validate the pipeline and apply it to outpatients presenting with mild...

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The Damaraland mole-rat (DMR; Fukomys damarensis) is a long-lived (~ 20 years) Bathyergid rodent that diverged 26 million years ago from its close relative, the naked mole-rat (NMR). While the properties of NMR cultured fibroblasts have been extensively studied and have revealed several unusual features of this cancer-resistant, long-lived species, comparative DMR studies are extremely limited. We optimized conditions for successfully culturing primary DMR skin fibroblasts and also established...

The accumulation of senescent cells can lead to tissue degeneration, chronic inflammatory disease and age-related tumorigenesis. Interventions such as senolytics are currently limited by off-target toxicity, which could be circumvented by instead enhancing immune-mediated senescent cell clearance; however, immune surveillance of senescent cells is often impeded by immunosuppressive factors in the inflammatory microenvironment. Here, we employ a chimeric peptide as a 'matchmaker' to bind to the...

CONCLUSION: In older adults with SBP < 130 mmHg, DBP values 80-89 mmHg were not associated with higher risk of CV organ damage, events or mortality.

CONCLUSIONS: These findings suggest that individuals who participated more frequently in more leisure activities had a higher chance of the maintenance of successful aging in older adults. Encouraging older people to frequently participate in a greater variety of leisure activities may be an effective way to maintain successful aging over time.

CONCLUSION: This study demonstrates a bidirectional causal relationship between self-perceptions of aging and frailty, with subjective cognitive decline identified as a mediating mechanism. These findings provide important guidance for future efforts aimed at reducing frailty rates among older adults in community settings.

The world faces a global challenge of how to meet the nutritional needs of a diverse global population through diets. This paper defines the relative nutritional needs across each stage of the life cycle to support human health and identifies who is nutritionally vulnerable. Findings in this paper suggest that there are biological nutritional vulnerabilities stemming from high micronutrient needs per calorie in certain phases of the life cycle, particularly for infants and young children, women...

Across the lifespan, diet and physical activity profiles substantially influence immunometabolic health. DNA methylation, as a tissue-specific marker sensitive to behavioral change, may mediate these effects through modulation of transcription factor binding and subsequent gene expression. Despite this, few human studies have profiled DNA methylation and gene expression simultaneously in multiple tissues or examined how molecular levels react and interact in response to lifestyle changes. The...

CONCLUSIONS: Our findings suggest that NORC residents have greater health needs than other older adults living in the community and underscore NORCs as important targets for equity-focused strategies to support aging in place.

The chronic inflammation present in aged individuals is generally depicted as a detrimental player for longevity. Here, it is discussed several beneficial effects associated with the cytokines that are chronically elevated in inflammaging. These cytokines, such as IL-1β, type I interferons, IL-6 and TNF positively regulate macroautophagy, mitochondrial function, anti-tumor immune responses and skeletal muscle biogenesis, possibly contributing to longevity. On the other side, the detrimental and...