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Circadian clocks regulate a myriad of physiological processes rhythmically throughout the day in most organisms. Our study focuses on a relatively less-studied neuropeptide CCHamide1 (CCHa1), expressed in the Drosophila melanogaster gut and the central circadian clock in the brain. We investigated the role of ccha1 on sleep under altered dietary conditions, as well as its impact on metabolism and fitness in Drosophila. We assayed sleep under ad libitum fed, starved and altered protein diets...

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Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide, and ageing is their strongest biological risk factor. In the ageing cardiovascular system, mitochondrial dysfunction is not only a central driver of disease progression but also a key feature of cardiovascular ageing, linking oxidative stress, calcium dysregulation, bioenergetic failure, impaired mitochondrial dynamics, defective mitophagy, and chronic inflammation to myocardial and vascular decline. In...

Osteoarthritis (OA) is a prevalent age-associated joint disease marked by progressive cartilage loss, subchondral bone remodeling, osteophyte formation, and low-grade inflammation. In OA, articular chondrocytes shift from a stable extracellular matrix (ECM)-maintaining state toward a hypertrophy-like program with increased collagen type X alpha 1 chain (COL10A1), runt-related transcription factor 2 (RUNX2), and matrix metalloproteinase 13 (MMP-13), promoting ECM degradation, calcification, and...

Sleep disorders and cardiovascular diseases are pressing global health concerns, whose prevalence and comorbidity significantly increase with age. The mechanistic underpinnings of this bidirectional relationship remain elusive. This review posits the Gut-Brain-Heart Axis (GBHA) as a critical integrative network bridging this clinical gap, particularly in the context of ageing. We synthesize compelling evidence that sleep disturbances induce gut dysbiosis, compromise intestinal barrier...

Multidrug resistance (MDR) compromises cancer treatment efficacy and leads to therapeutic failure. Therapy-induced senescence further complicates MDR through senescence-enhanced drug efflux and senescence-associated secretory phenotypes (SASPs), remaining a huge challenge. Here, we develop a self-generative senescence-associated β-galactosidase (SA-β-gal)-initiated chemical anchoring of lysosomal protein approach to counteract drug efflux and reprogram SASPs. A senescence-tumor-targeted...

Ageing is the primary risk factor for many chronic, degenerative, and life-threatening disorders, yet the translational pipeline for geroprotective interventions remains comparatively sparse. Short‑lived, experimentally tractable models with conserved ageing pathways, particularly Caenorhabditis elegans, Drosophila melanogaster, and the African turquoise killifish (Nothobranchius furzeri), have expanded discovery beyond traditionally mammalian-centric pipelines. By leveraging advances in...