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Unveiling aging heterogeneities in human dermal fibroblasts via nanosensor chemical cytometry

6 months 4 weeks ago
Aging heterogeneity in tissue-regenerative cells leads to variable therapeutic outcomes, complicating quality control and clinical predictability. Conventional analytical methods relying on labeling or cell lysis are destructive and incompatible with downstream therapeutic applications. Here we show a label-free, nondestructive single-cell analysis platform based on nanosensor chemical cytometry (NCC), integrated with automated hardware and deep learning. nIR fluorescent single-walled carbon...
Youngho Song

Psilocybin treatment extends cellular lifespan and improves survival of aged mice

6 months 4 weeks ago
Psilocybin, the naturally occurring psychedelic compound produced by hallucinogenic mushrooms, has received attention due to considerable clinical evidence for its therapeutic potential to treat various psychiatric and neurodegenerative indications. However, the underlying molecular mechanisms remain enigmatic, and few studies have explored its systemic impacts. We provide the first experimental evidence that psilocin (the active metabolite of psilocybin) treatment extends cellular lifespan and...
Kosuke Kato