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Age-Dependent Regulation of Hippocampal Inflammation by the Mitochondrial Translocator Protein in Mice

6 months 1 week ago
The mitochondrial translocator protein (TSPO) is a biomarker of inflammation associated with neurodegenerative diseases, widely regarded to be upregulated in the aging brain. Here we investigated the interaction between aging and TSPO immunomodulatory function in the mouse hippocampus, a region severely affected in Alzheimer's Disease (AD). Surprisingly, we found that TSPO levels were decreased in brain innate immune populations in aging. Aging resulted in a reversal of TSPO knockout...
Kei Onn Lai

Identification of Senomorphic miRNAs in Embryonic Progenitor and Adult Stem Cell-Derived Extracellular Vesicles

6 months 1 week ago
Extracellular vesicles (EVs) are secreted by most cell types, transmitting crucial signaling molecules like proteins, small RNAs, and DNA. We previously demonstrated that EVs from murine and human mesenchymal stem cells (MSCs) functioned as senomorphics to suppress markers of senescence and the inflammatory senescence-associated secretory phenotype (SASP) in cell culture and in aged mice. Here we demonstrate that EVs from additional types of human adult stem cells and embryonic progenitor cells...
Tianpeng Zhang

Age-Dependent Regulation of Hippocampal Inflammation by the Mitochondrial Translocator Protein in Mice

6 months 1 week ago
The mitochondrial translocator protein (TSPO) is a biomarker of inflammation associated with neurodegenerative diseases, widely regarded to be upregulated in the aging brain. Here we investigated the interaction between aging and TSPO immunomodulatory function in the mouse hippocampus, a region severely affected in Alzheimer's Disease (AD). Surprisingly, we found that TSPO levels were decreased in brain innate immune populations in aging. Aging resulted in a reversal of TSPO knockout...
Kei Onn Lai

Base-modified nucleotides mediate immune signaling in bacteria

6 months 1 week ago
Science, Volume 388, Issue 6745, April 2025.
Zhifeng Zeng, Zeyu Hu, Ruiliang Zhao, Jikai Rao, Mario Rodríguez Mestre, Yanqiu Liu, Shunhang Liu, Hao Feng, Yu Chen, Huan He, Nuo Chen, Jinshui Zheng, Donghai Peng, Min Luo, Qunxin She, Rafael Pinilla-Redondo, Wenyuan Han