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Age-Dependent Regulation of Hippocampal Inflammation by the Mitochondrial Translocator Protein in Mice
The mitochondrial translocator protein (TSPO) is a biomarker of inflammation associated with neurodegenerative diseases, widely regarded to be upregulated in the aging brain. Here we investigated the interaction between aging and TSPO immunomodulatory function in the mouse hippocampus, a region severely affected in Alzheimer's Disease (AD). Surprisingly, we found that TSPO levels were decreased in brain innate immune populations in aging. Aging resulted in a reversal of TSPO knockout...
Identification of Senomorphic miRNAs in Embryonic Progenitor and Adult Stem Cell-Derived Extracellular Vesicles
Extracellular vesicles (EVs) are secreted by most cell types, transmitting crucial signaling molecules like proteins, small RNAs, and DNA. We previously demonstrated that EVs from murine and human mesenchymal stem cells (MSCs) functioned as senomorphics to suppress markers of senescence and the inflammatory senescence-associated secretory phenotype (SASP) in cell culture and in aged mice. Here we demonstrate that EVs from additional types of human adult stem cells and embryonic progenitor cells...
Age-Dependent Regulation of Hippocampal Inflammation by the Mitochondrial Translocator Protein in Mice
The mitochondrial translocator protein (TSPO) is a biomarker of inflammation associated with neurodegenerative diseases, widely regarded to be upregulated in the aging brain. Here we investigated the interaction between aging and TSPO immunomodulatory function in the mouse hippocampus, a region severely affected in Alzheimer's Disease (AD). Surprisingly, we found that TSPO levels were decreased in brain innate immune populations in aging. Aging resulted in a reversal of TSPO knockout...
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Science, Volume 388, Issue 6745, April 2025.
Structural mechanism of LINE-1 target-primed reverse transcription
Science, Volume 388, Issue 6745, April 2025.
Base-modified nucleotides mediate immune signaling in bacteria
Science, Volume 388, Issue 6745, April 2025.
Tumor-derived erythropoietin acts as an immunosuppressive switch in cancer immunity
Science, Volume 388, Issue 6745, April 2025.
Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle in the United States
Science, Volume 388, Issue 6745, April 2025.
Distinct adipose progenitor cells emerging with age drive active adipogenesis
Science, Volume 388, Issue 6745, April 2025.
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