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Aging impaired locomotor and biochemical activities in Drosophila melanogaster Oregon R (fruit fly) model
Despite advancements in healthcare and increased lifespan, aging populations face numerous challenges, including declining cognitive function, increased susceptibility to chronic diseases, and reduced quality of life. This study investigated Aging impaired Locomotors and Biochemical Activities in Drosophila melanogaster Oregon R (Fruit Fly) Model with the aim to elucidate the mechanism involved. Adult wild-type Drosophila melanogaster Oregon R was used for this study. Survival assay, antioxidant...
The mitochondrial function of peripheral blood mononuclear cells in frail older patients
CONCLUSION: Mitochondrial dysfunctions (decreased mtDNAcn, impaired mitochondrial morphology, imbalanced mitochondrial dynamic, impaired mitochondrial respiratory function, and increased ROS levels) were significantly correlated with frail status.
Structural features within the NORAD long noncoding RNA underlie efficient repression of Pumilio activity
Long noncoding RNAs (lncRNAs) are increasingly appreciated for their important functions in mammalian cells. However, how their functional capacities are encoded in their sequences and manifested in their structures remains largely unknown. Some lncRNAs bind to and modulate the availability of RNA-binding proteins, but the structural principles that underlie this mode of regulation are unknown. The NORAD lncRNA is a known decoy for Pumilio proteins, which modulate the translation and stability...
The practical longevity of stockpiled A(H5N1) influenza vaccine
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Author Correction: The role of the haematopoietic stem cell niche in development and ageing
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The effects of APOEe4 allele on cerebral structure, function, and related interactions with cognition in young adults
In the last decade, extensive research has emerged into understanding the impact of risk factors for Alzheimer's Disease (AD) on brain in pre-symptomatic stages. We investigated the neuroimaging correlates of the APOEe4 genetic risk factor for AD in young adulthood, its relationship with cognition, and potential effects of other variables on the findings. While conventional volumetric analyses revealed no consistent differences, more sophisticated analyses identified subtle structural...
Daily Briefing: Drugs like Ozempic seem to help everything from Alzheimer's to infertility. But how?
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Picture imperfect
Did a top NIH official, neuroscientist Eliezer Masliah, doctor influential Alzheimer's and Parkinson's studies for decades?
Did a top NIH official manipulate Alzheimer's and Parkinson’s studies for decades?
Agency announces research misconduct finding for neuroscientist Eliezer Masliah as scores of his papers fall under suspicion
Daily briefing: Bigger chatbots tell more lies
The revolution in high-throughput proteomics and AI
Science, Volume 385, Issue 6716, September 2024.
Erratum for the Research Article “Electrically driven proton transfer promotes Brønsted acid catalysis by orders of magnitude” by K. S. Westendorff et al.
Science, Volume 385, Issue 6716, September 2024.
Erratum for the Review “The microbiome and human cancer” by G. D. Sepich-Poore et al.
Science, Volume 385, Issue 6716, September 2024.