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Environmental and societal consequences of winter ice loss from lakes

6 months 1 week ago
Science, Volume 386, Issue 6718, October 2024.
Stephanie E. Hampton, Stephen M. Powers, Hilary A. Dugan, Lesley B. Knoll, Bailey C. McMeans, Michael F. Meyer, Catherine M. O’Reilly, Ted Ozersky, Sapna Sharma, David C. Barrett, Sudeep Chandra, Joachim Jansen, Ryan P. McClure, Milla Rautio, Gesa A…

Uncovering mediational pathways behind racial and socioeconomic disparities in brain volumes: insights from the UK Biobank study

6 months 1 week ago
Mediation pathways explaining racial/ethnic and socioeconomic (SES) disparities in structural MRI markers of brain health remain underexplored. We examined racial/ethnic and SES disparities in sMRI markers and tested total, direct, and indirect effects through lifestyle, health-related, and cognition factors using a structural equations modeling approach among 36,184 UK Biobank participants aged 40-70 years at baseline assessment (47% men). Race (non-White vs. White) and lower SES-predicted...
May A Beydoun

Small molecule modulators of alpha-synuclein aggregation and toxicity: Pioneering an emerging arsenal against Parkinson's disease

6 months 1 week ago
Parkinson's disease (PD) is primarily characterized by loss of dopaminergic neurons in the substantia nigra pars compacta region of the brain and accumulation of aggregated forms of alpha-synuclein (α-Syn), an intrinsically disordered protein, in the form of Lewy Bodies and Lewy Neurites. Substantial evidences point to the aggregated/fibrillar forms of α-Syn as a central event in PD pathogenesis, underscoring the modulation of α-Syn aggregation as a promising strategy for PD treatment....
Ishfaq Ahmad Ahanger

Serotonin in depression and Alzheimer's disease: Focus on SSRI's beneficial effects

6 months 1 week ago
Depression is a complex and pervasive mental health disorder affecting millions globally. Serotonin, a critical neurotransmitter, plays a central role in the pathophysiology of depression. This review explores serotonin's multifaceted role in depression, focusing on its synthesis, bioavailability, receptor interactions, and the impact of various factors, including diet, stress, and gender differences. This review aims to provide a comprehensive understanding of serotonin's role in depression by...
Jihane Tahiri

Biotics as novel therapeutics in targeting signs of skin ageing via the gut-skin axis

6 months 1 week ago
Skin ageing is a phenomenon resulting from the aggregative changes to skin structure and function and is clinically manifested by physical features such as wrinkles, hyperpigmentation, elastosis, telangiectasia, and deterioration of skin barrier integrity. One of the main drivers of skin ageing, UV radiation, negatively influences the homeostasis of cells and tissues comprising the skin by triggering production of immune-mediated reactive oxygen species (ROS) and pro-inflammatory cytokines, as...
Jasmine F Millman

Spatial learning and memory impairment at the post-follicular depletion state is associated with reduced hippocampal glucose uptake

6 months 1 week ago
The menopausal transition is a complex neuroendocrine aging process affecting brain structure and metabolic function. Such changes are consistent with neurological sequelae noted following the menopausal transition, including cognitive deficits. Although studies in rodent models of the menopause revealed changes in learning and memory, little is known about the structural and metabolic changes in the brain regions serving the cognitive function in these models. The administration...
Nur Zuliani Ramli