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Moonstruck: tropical mammals take their cues from lunar cycles
Daily briefing: ‘Neural tourniquet’ could stem bleeding by stimulating nerves
What drives me to help female students to thrive at my Ugandan university
Restore Internet access in war-torn Sudan
Converting chaos into order: aerial archaeology takes flight in the 1920s
Dairy cows inoculated with highly pathogenic avian influenza virus H5N1
LGBTQ older adults deserve safe and affirming housing
The early days of peer review: five insights from historical reports
The UN needs a new mission: get stuff done
AI has dreamt up a blizzard of new proteins. Do any of them actually work?
Black women on the academic tightrope: four scholars weigh in
Just widening access to the right drugs won’t solve antimicrobial resistance
Conflict in New Caledonia endangers one of the world’s biodiversity hotspots
UN plastic pollution treaty must not ignore the scourge of microplastics
Why did an obscure virus explode in Latin America? New study offers clues
Major genetic changes may have made the Oropouche more virulent, researchers say
A mixed review for Plan S’s drive to make papers open access
Evaluation describes unintended effects as funders mull expanding the policy
Belt-tightening budget derails France’s multiyear research funding plan
Amid across-the-board spending cuts, France fails to meet targets for decadelong plan to better support science
Clustering lysosomes around the MTOC: a promising strategy for SNCA/alpha-synuclein breakdown leading to parkinson disease treatment
Macroautophagy/autophagy maintains cellular homeostasis by degrading cytoplasmic components and its disruption is linked to Parkinson disease (PD), which is characterized by dopamine depletion and the accumulation of SNCA/α-synuclein aggregates in neurons. Therefore, activation of autophagy is considered a therapeutic strategy for PD; however, autophagy inducers have not yet been developed as therapeutic drugs because they are involved in a wide range of signaling pathways. Here, we focused on...
SEA-AD is a multimodal cellular atlas and resource for Alzheimer's disease
No abstract
Integrated multimodal cell atlas of Alzheimer's disease
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD progression is characterized by stereotyped accumulation of proteinopathies, the affected cellular populations remain understudied. Here we use multiomics, spatial genomics and reference atlases from the BRAIN Initiative to study middle temporal gyrus cell types in 84 donors with varying AD pathologies. This cohort includes 33 male donors and 51 female donors, with an average age at time of death of 88 years....