Aggregator

In Other Journals

6 months ago
Science, Volume 387, Issue 6729, Page 36-37, January 2025.

Corinne Simonti, and
Jesse Smith,
Di Jiang,
Bianca Lopez,
Sarah H. Ross,
Jelena Stajic,
Jesse Smith,
Michael A. Funk, and
Caroline Ash

Deep learning predicts DNA methylation regulatory variants in specific brain cell types and enhances fine mapping for brain disorders

6 months ago
DNA methylation (DNAm) is essential for brain development and function and potentially mediates the effects of genetic risk variants underlying brain disorders. We present INTERACT, a transformer-based deep learning model to predict regulatory variants affecting DNAm levels in specific brain cell types, leveraging existing single-nucleus DNAm data from the human brain. We show that INTERACT accurately predicts cell type-specific DNAm profiles, achieving an average area under the receiver...
Jiyun Zhou

Increased alpha-synuclein phosphorylation and oligomerization and altered enzymes in plasma of patients with Parkinson's disease

6 months ago
The brain of patients with Parkinson's disease (PD) was characterized by increased phosphorylation and oligomerization of α-synuclein (α-syn) and altered activity of enzymes regulating α-syn phosphorylation and oligomerization. Whether increased α-syn phosphorylation and oligomerization as well as related enzyme changes can be detected in the plasma of PD patients remains unclear. Here, we showed that human α-syn proteins incubated in PD plasma formed more oligomerized α-syn (O-α-syn) and...
Na Yin