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Microglia Single-Cell RNA-Seq Enables Robust and Applicable Markers of Biological Aging
"Biological aging clocks"-composite molecular markers thought to capture an individual's biological age-have been traditionally developed through bulk-level analyses of mixed cells and tissues. However, recent evidence highlights the importance of gaining single-cell-level insights into the aging process. Microglia are key immune cells in the brain shown to adapt functionally in aging and disease. Recent studies have generated single-cell RNA-sequencing (scRNA-seq) datasets that...
UTX (KDM6A) promotes differentiation noncatalytically in somatic self-renewing epithelia
The X-linked histone demethylase, UTX (KDM6A), is a master regulator of gene enhancers, though its role in self-renewing epithelia like the skin is not well understood. Here, we find that UTX is a key regulator of skin differentiation via the regulation of retinoic acid (RA) signaling, an essential metabolic pathway in both skin homeostasis, as well as in the treatment of an array of skin conditions ranging from cancer and acne to aging. Through deletion of Utx in the skin, we demonstrate direct...
Amyloid-beta peptide toxicity in the aged brain is a one-way journey into Alzheimer's disease
Aging is the primary risk factor for Alzheimer's disease (AD), and the aging brain shares many characteristics with the early stages of AD. This study investigates the interplay between aging and amyloid-beta (Aβ) induced pathology. We developed an AD-like in vivo model, using the stereotactic injection of Aβ(1-42) oligomers into the hippocampi of aged mice. Cognitive impairments were assessed using a Y maze. Immunohistochemical and protein analyses were conducted to evaluate neuronal survival,...
The Redox Activity of Protein Disulphide Isomerase Functions in Non-Homologous End-Joining Repair to Prevent DNA Damage
DNA damage is a serious threat to cellular viability, and it is implicated as the major cause of normal ageing. Hence, targeting DNA damage therapeutically may counteract age-related cellular dysfunction and disease, such as neurodegenerative conditions and cancer. Identifying novel DNA repair mechanisms therefore reveals new therapeutic interventions for multiple human diseases. In neurons, non-homologous end-joining (NHEJ) is the only mechanism available to repair double-stranded DNA breaks...
Explosive volcanoes can bury carbon —a climate boon
Daily briefing: Yes, you can find love during your PhD
Powerful CRISPR system inserts whole gene into human DNA
World’s first personalized CRISPR therapy given to baby with genetic disease
The world’s richest people have an outsized role in climate extremes
How CAR-T cancer therapies could harm the brain
On the economic costs of ending DEI
Science, Volume 388, Issue 6748, May 2025.
Erratum for the Report “Recognition of a ubiquitous self antigen by prostate cancer–infiltrating CD8+ T lymphocytes” by P. A. Savage et al.
Science, Volume 388, Issue 6748, May 2025.
Admixture’s impact on Brazilian population evolution and health
Science, Volume 388, Issue 6748, May 2025.
Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase
Science, Volume 388, Issue 6748, May 2025.
Cryptic infection of a giant virus in a unicellular green alga
Science, Volume 388, Issue 6748, May 2025.
Activation dynamics traced through a G protein–coupled receptor by 81 1H-15N NMR probes
Science, Volume 388, Issue 6748, May 2025.
Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis
Science, Volume 388, Issue 6748, May 2025.
From North Asia to South America: Tracing the longest human migration through genomic sequencing
Science, Volume 388, Issue 6748, May 2025.