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A transient neurohormonal circuit controls hatching in fish
Science, Volume 386, Issue 6726, Page 1173-1178, December 2024.
Active-reset protein sensors enable continuous in vivo monitoring of inflammation
Science, Volume 386, Issue 6726, Page 1146-1153, December 2024.
On the origins of organisms
Science, Volume 386, Issue 6726, Page 1098-1099, December 2024.
Scopes monkey trial, in context
Science, Volume 386, Issue 6726, Page 1100-1100, December 2024.
Why hasn’t the bird flu pandemic started?
Some scientists examining mutations found in H5N1 viruses fear major outbreak is imminent but others say pathogen remains unpredictable
Apex the Stegosaur, the most expensive dinosaur fossil ever sold, heads to a museum
The American Museum of Natural History will host one of the most complete Stegosaurus specimens for the next 4 years
NIH needs a new institute for women’s health research, expert panel says
National Academies report also calls for $16 billion in new money
News at a glance: Orange cats, COVID-19 origin probe, and a collapse of plastic treaty talks
The latest in science and policy
Latin American journals are open-access pioneers. Now, they need an audience
SciElo, other platforms work to help journals reach readers around the world
An overview on the impact of viral pathogens on Alzheimer's disease
Alzheimer's disease (AD) is the most common type of dementia which affects over than 60 million cases worldwide with higher incidence in low and middle-income countries by 2030. Based on the multifactorial nature of AD different risk factors are linked to the condition considering the brain's β-amyloid plaques (Aβ) and neurofibrillary tangles (NFTs) as its primary hallmarks. Lately, viral photogenes specially after recent SARS-CoV-2 pandemic has gained a lot of attention in promoting the...
<em>Hydra</em> has mammal-like mutation rates facilitating fast adaptation despite its nonaging phenotype
Growing evidence suggests that somatic mutations may be a major cause of the aging process. However, it remains to be tested whether the predictions of the theory also apply to species with longer life spans than humans. Hydra is a genus of freshwater polyps with remarkable regeneration abilities and a potentially unlimited life span under laboratory conditions. By genome sequencing of single cells and whole animals, we found that the mutation rates in Hydra's stem cells are even slightly higher...
Women and aging
No abstract
An online driving decision aid for older drivers reduces ambivalence and regret about driving decisions: Randomized trial
CONCLUSIONS: In older drivers, the Healthwise® DDA reduced uncertainty and regret about driving decisions during longitudinal follow-up, without adversely affecting community mobility or crash risk. Use of DDAs in clinical and other settings may reduce the distress older adults often experience when making decisions about driving cessation.
RANKL treatment restores thymic function and improves T cell-mediated immune responses in aged mice
Age-related thymic involution, leading to reduced T cell production, is one of the major causes of immunosenescence. This results in an increased susceptibility to cancers, infections, and autoimmunity and in reduced vaccine efficacy. Here, we identified that the receptor activator of nuclear factor κB (RANK)-RANK ligand (RANKL) axis in the thymus is altered during aging. Using a conditional transgenic mouse model, we demonstrated that endothelial cells depend on RANK signaling for their...
Skeletal muscle mitochondrial fragmentation predicts age-associated decline in physical capacity
Ageing substantially impairs skeletal muscle metabolic and physical function. Skeletal muscle mitochondrial health is also impaired with ageing, but the role of skeletal muscle mitochondrial fragmentation in age-related functional decline remains imprecisely characterized. Here, using a cross-sectional study design, we performed a detailed comparison of skeletal muscle mitochondrial characteristics in relation to in vivo markers of exercise capacity between young and middle-aged individuals....
Gut microbiota metabolism of branched-chain amino acids and their metabolites can improve the physiological function of aging mice
The metabolism of branched-chain amino acids by gut microbiota can improve overall health and may reverse aging. In this study, we investigated Parabacteroides merdae, a gut microbe that is known to catabolise branched-chain amino acids (BCAAs). Three metabolites of BCAAs isovalerate, 2-methylbutyrate, and isobutyrate were used to treat D-gal induced aging mice. The results showed that these treatments could delay aging in mice by providing health benefits in reducing oxidative stress and...