Aging & Longevity

Aging Compromises Terminal Differentiation Program of Cytotoxic Effector Lineage and Promotes Exhaustion in CD8(+) T Cells Responding to Coronavirus Infection

3 months 3 weeks ago
T cell aging increases the risk of viral infection-related morbidity and mortality and reduces vaccine efficacy in the elderly. A major hallmark of T cell aging is the loss of quiescence and shift toward terminal differentiation during homeostasis. However, how aging impacts the differentiation program of virus-specific T cells during infection is unclear. Here, in a murine coronavirus (MHV) infection model with age-associated increased mortality, we demonstrate that aging impairs, instead of...
Ziang Zhu

Chromogranin A deficiency attenuates tauopathy by altering epinephrine-alpha-adrenergic receptor signaling in PS19 mice

3 months 3 weeks ago
Metabolic disorders such as insulin resistance and hypertension are potential risk factors for aging and neurodegenerative diseases. These conditions are reversed in Chromogranin A (CgA) knockout (CgA-KO) mice. CgA is known to be associated with protein aggregates in the brains of neurodegenerative diseases including Alzheimer's disease (AD). Here, we investigated the role of CgA in Tau pathogenesis in AD and corticobasal degeneration (CBD). CgA ablation in Tauopathy mice (PS19) (CgA-KO/PS19)...
Suborno Jati

Age-associated nicotinamide adenine dinucleotide decline drives CAR-T cell failure

3 months 3 weeks ago
Chimeric antigen receptor (CAR) T cell therapy is one of the most promising cancer treatments. However, different hurdles are limiting its application and efficacy. In this context, how aging influences CAR-T cell outcomes is largely unknown. Here we show that CAR-T cells generated from aged female mice present a mitochondrial dysfunction derived from nicotinamide adenine dinucleotide (NAD) depletion that leads to poor stem-like properties and limited functionality in vivo. Moreover, human data...
Helen Carrasco Hope

mRNA metabolism regulator human antigen R (HuR) regulates age-related hearing loss in aged mice

3 months 3 weeks ago
Age-related hearing loss (ARHL) is among the most prevalent and complex disorders in older adults. However, the pathogenesis of ARHL remains poorly understood. Using a single-cell transcriptomic landscape of mouse cochlea at five time points (1, 2, 5, 12 and 15 months), we found that the levels of human antigen R (HuR)-a classical RNA-binding protein-increase with age. Here we show that HuR is specifically transported from the nucleus to the cytoplasm in hair cells in both aging mice and...
Siwei Guo

Endometrial aging is accompanied by H3K27ac and PGR loss

3 months 3 weeks ago
Whether and how endometrial aging affects fertility remains unclear. In our in-house clinical cohort at the Center for Reproductive Medicine of Peking University Third Hospital (n = 1,149), we observed adverse pregnancy outcomes in the middle-aged group after excluding aneuploid embryos, implying the negative impact of endometrial aging on fertility. To understand endometrial aging, we performed comprehensive transcriptomic profiling of the mid-secretory endometrium of young (<35 years) and...
Yue Wang

A dynamic and multimodal framework to define microglial states

3 months 3 weeks ago
The widespread use of single-cell RNA sequencing has generated numerous purportedly distinct and novel subsets of microglia. Here, we challenge this fragmented paradigm by proposing that microglia exist along a continuum rather than as discrete entities. We identify a methodological over-reliance on computational clustering algorithms as the fundamental issue, with arbitrary cluster numbers being interpreted as biological reality. Evidence suggests that the observed transcriptional diversity...
Roman Sankowski

Stepping through fear: analysing postural control in elderly women during transitional locomotor tasks

3 months 3 weeks ago
CONCLUSION: The study concludes that while FoF does not impair static balance, it significantly impacts movement initiation and execution in transitional tasks. Prolonged preparation time (S1) in the HIGH FoF group highlights the role of fear in delaying movement. These findings are important for designing interventions to reduce FoF and prevent falls in older adults.
Justyna Michalska

A monocentric prospective study investigating digital engagement among geriatric hospital patients

3 months 3 weeks ago
CONCLUSION: Our findings align with previous studies involving participants of comparable age, indicating comparable results, apart from disease-related participation restrictions. However, the significant proportion of patients who did not want to participate (55.7%) and the analysis of the reasons for nonparticipation suggest that the actual number of geriatric patients who do not engage online is higher. While this does not necessarily imply a complete rejection of digital products by this...
Julia Göbel

Population size interacts with reproductive longevity to shape the germline mutation rate

3 months 3 weeks ago
Mutation rates vary across the tree of life by many orders of magnitude, with fewer mutations occurring each generation in species that reproduce quickly and maintain large effective population sizes. A compelling explanation is that large effective population sizes facilitate selection against weakly deleterious "mutator alleles" such as variants that modulate cell division or interfere with the molecular efficacy of DNA repair. However, while the fidelity of a single cell division largely...
Luke Zhu

The Association Between Nutritional Status, Diet Quality, and Sleep Quality Among the Elderly in Jordan: A Cross-Sectional Study

3 months 3 weeks ago
Background: The percentage of the elderly population has increased worldwide. It has been estimated that environmental factors such as eating habits, sleep quality, and physical activity could be responsible for up to 75% of the aging process. Aims: To assess the nutritional status, diet quality, and sleep quality among the elderly in Jordanian. Methods: In a cross-sectional study targeting the Jordanian elderly, 426 participants agreed to participate. Sociodemographic data, anthropometric...
Shadan Al-Tal

Sex-specific insights into drug-induced lifespan extension and weight loss in mice

3 months 3 weeks ago
The DrugAge database serves as a comprehensive resource for studying compounds that increase lifespan in model organisms. In the latest version of DrugAge, we implemented multiple updates, predominantly focusing on mouse studies to enhance data accuracy and consistency. Key improvements include re-recording of mouse data from original sources, standardization of drug dosages to parts per million, and recording of administration routes, treatment initiation ages, and lifespans of controls. The...
Aleksey V Belikov

Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis

3 months 3 weeks ago
With increased age, the liver becomes more vulnerable to metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis. Deciphering the complex interplay between aging, the emergence of senescent cells in the liver and MASH fibrosis is critical for developing treatments. Here we report an epigenetic mechanism that links liver aging to MASH fibrosis. We find that upregulation of the chromatin remodeler BAZ2B in a subpopulation of hepatocytes (HEPs) is linked to MASH pathology in patients....
Chuantao Tu

Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis

3 months 3 weeks ago
The pace of life syndrome (POLS) hypothesis suggests that organisms' life history and physiological and behavioural traits should co-evolve. In this framework, how glycaemia (i.e. blood glucose levels) and its reaction with proteins and other compounds (i.e. glycation) covary with life history traits remain relatively under-investigated, despite the well-documented consequences of glucose and glycation on ageing, and therefore potentially on life history evolution. Birds are particularly...
Adrián Moreno Borrallo

Immunosenescence Profile Is Associated With Increased Susceptibility to Severe COVID-19

3 months 3 weeks ago
In this study, we tested the hypothesis that the immunosenescence profile could account for the disproportional susceptibility of the elderly to severe forms of COVID-19. The immunological profiles of volunteers residing in endemic and non-endemic areas for chronic infectious diseases were analyzed at the early stage of SARS-CoV-2 infection. A unique signature of inflammatory plasma mediators was identified in COVID-19 volunteers when compared to individuals with other flu-like syndromes....
Lucas Haniel A Ventura
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