Aging & Longevity

Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape

2 months 2 weeks ago
Aging is reflected by genome-wide DNA methylation changes, which form the basis of epigenetic clocks, but it is largely unclear how these epigenetic modifications are regulated and whether they directly affect the aging process. In this study, we performed epigenetic editing at age-associated CpG sites to explore the consequences of interfering with epigenetic clocks. CRISPR-guided editing targeted at individual age-related CpGs evoked genome-wide bystander effects, which were highly...
Sven Liesenfelder

Drug-Based Lifespan Extension in Mice Strongly Affects Lipids Across Six Organs

2 months 2 weeks ago
Caloric restriction is associated with slow aging in model organisms. Additionally, some drugs have also been shown to slow aging in rodents. To better understand metabolic mechanisms that are involved in increased lifespan, we analyzed metabolomic differences in six organs of 12-month-old mice using five interventions leading to extended longevity, specifically caloric restriction, 17-α estradiol, and caloric restriction mimetics rapamycin, canagliflozin, and acarbose. These interventions...
Sara Greenfield

Ordered zinc electrodeposition from single-crystal units to polycrystalline stacking within solid-electrolyte interphase in battery anodes

2 months 2 weeks ago
Controlling Zinc (Zn) nucleation and subsequent crystal growth are critical for long lifespan aqueous zinc metal batteries. However, the concurrent side reactions and unstable solid-electrolyte interphase (SEI) formations impedes the continuous Zn metal electrodeposition. Herein, induced by a well-designed organic/inorganic dual-phase SEI, we realize ordered zinc electrodeposition of polycrystalline stackings from single-crystal building blocks. The uncommon SEI with appropriate ion transport...
Ming Zhao

Religiosity, Religious Beliefs, and Cognitive Impairment Among Black and White Men With Modest Incomes

2 months 2 weeks ago
ObjectiveThe objective of this study was to examine the association between religious practices, beliefs, and cognitive impairment among Black and White men with modest incomes in the 2016 Health and Retirement Study.MethodsData were drawn from Black and White men who reported annual incomes at or below $50,000 (n = 926). The primary outcome was any cognitive impairment, a dichotomous variable derived from a modified version of the Telephone Interview for Cognitive Status. The religious...
Marino A Bruce

Advancing Alzheimer's Disease and Related Dementias Research: The Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research

2 months 2 weeks ago
ObjectiveThis article introduces a special issue on advancing Alzheimer's disease (AD) and AD-related dementias (ADRD) research drawing from research conducted by the Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research (JHAD-RCMAR).MethodWe describe the JHAD-RCMAR, highlighting work of early career investigators in the JHAD-RCMAR, summarize key accomplishments, and propose recommendations for next steps in ameliorating disparities in cognitive decline and AD/ADRD...
George W Rebok

Race and Incident Dementia Among Older Black and Older White Men

2 months 2 weeks ago
The objective of this study was to determine if racial differences exist between older Non-Hispanic Black (NHB) and White (NHW) men in incident dementia over 11 years (2011-2022) in the National Health and Aging Trends Study (NHATS). The analytic sample included 2395 community-dwelling NHB and NHW men free of dementia at baseline who self-identified as Non-Hispanic Black (NHB) and White (NHW). Dementia was assessed at each visit using a validated algorithm developed by NHATS. After adjusting for...
Bosola Jerry-Asooto

Longitudinal Engagement in Modifiable Lifestyle Behaviors and Racial-Ethnic Differences in Dementia Risk

2 months 2 weeks ago
ObjectivesThe objective was to examine racial-ethnic differences in longitudinal engagement for lifestyle behaviors and moderating role of race-ethnicity between lifestyle behaviors and dementia risk.MethodsWe analyzed 2011-2021 National Health and Aging Trends Study data, a nationally representative U.S. sample of 6155 White, Black, Hispanic, and Asian older adults aged 65+. Cox models regressed dementia on the interaction between lifestyle behaviors (physical activity, smoking, and social...
Roger Wong

Subjective Cognitive Impairment (SCI) and Future Dementia Risk in the National Health and Aging Trends Study (NHATS) During 2012-2019

2 months 2 weeks ago
BackgroundSubjective cognitive impairment (SCI), assessed in national surveys, offers potential for dementia monitoring and early detection. However, its causal link to dementia risk remains unclear.ObjectiveTo evaluate whether SCI causally affects dementia risk in U.S. older adults (≥65 years), considering mortality as a competing risk.MethodsUsing data from 1622 dementia-free older adults in the National Health and Aging Trends Study (NHATS) during 2011-2019, we estimated total, direct, and...
Emmanuel F Drabo

Long-term nucleus basalis cholinergic lesions alter the structure of cortical vasculature, astrocytic density and microglial activity in Wistar rats

2 months 2 weeks ago
Basal forebrain cholinergic neurons (BFCNs) are the sole source of cholinergic innervation to the cerebral cortex and hippocampus in humans and the primary source in rodents. This system undergoes early degeneration in Alzheimer's disease. BFCNs terminal synapses are involved in the regulation of the cerebral blood flow by making classical synaptic contacts with other neurons. Additionally, they are located in proximity to cortical cerebral blood vessels, forming connections with various cell...
Chiara Orciani

Age-related differences in resting glutamate levels and glutamate uptake in the hippocampus and frontal cortex of C57BL/6 mice

2 months 2 weeks ago
In normal aging, little is known in human and animal models about functional changes to glutamate neuronal systems that may contribute to age-related cognitive differences. The present studies investigated glutamate neuronal signaling in the hippocampus (dentate gyrus) and frontal cortex (infralimbic) of young adult (3-8 months), middle-aged (10-13 months), and aged (15-27 months) male and female C57BL/6 mice using microelectrode electrode array (MEA) recording technology to measure...
Francois Pomerleau

Conserved Biological Processes in Partial Cellular Reprogramming: Relevance to Aging and Rejuvenation

2 months 2 weeks ago
Partial or transient cellular reprogramming is defined by the limited induction of pluripotency factors without full dedifferentiation of cells to a pluripotent state. Comparing in vitro and in vivo mouse studies, and in vitro studies in humans, supported by visualizations of data interconnections, we show consistent patterns in how such reprogramming modulates key biological processes. Generally, partial reprogramming drives dynamic chromatin remodelling, involving histone modifications that...
Roberto A Avelar

Mitophagy in Alzheimer's disease and other metabolic disorders: A focus on mitochondrial-targeted therapeutics

2 months 2 weeks ago
Mitochondria, as central regulators of cellular processes such as energy production, apoptosis, and metabolic homeostasis, are essential to cellular function and health. The maintenance of mitochondrial integrity, especially through mitophagy-the selective removal of impaired mitochondria-is crucial for cellular homeostasis. Dysregulation of mitochondrial function, dynamics, and biogenesis is linked to neurodegenerative and metabolic diseases, notably Alzheimer's disease (AD), which is...
Shadt Skawratananond

Expression patterns of blood-based biomarkers of neurodegeneration and inflammation across adulthood in rhesus macaques

2 months 2 weeks ago
As the global human population rapidly ages and diseases of aging become more prevalent, preclinical models of age-related neurodegenerative disorders are increasingly important for identifying early diagnostic biomarkers, monitoring disease progression, and evaluating treatment responsiveness. Rhesus macaques are an ideal species for studies on neurodegeneration due to their phylogenetic relatedness to humans and their complex brain anatomy and physiology. Technological advances in assay...
Ludwig A P Metzler

Suicide Among Older People in Spain: The Role of Sex and Urbanicity

2 months 2 weeks ago
CONCLUSIONS: These results, highlighting recent increases in female suicides in urban areas and in specific method-specific male suicides both in rural and urban areas, and demonstrating geographical variation across regions, should help guide targeted suicide prevention efforts.
Gabriel Jesús Rodríguez-Rodríguez

Brain 5-hydroxymethylcytosine alterations are associated with Alzheimer's disease neuropathology

2 months 2 weeks ago
5-hydroxymethylcytosine, also known as the sixth DNA base of the genome, plays an important role in brain aging and neurological disorders such as Alzheimer's disease. However, little is known about its genome-wide distribution and its association with Alzheimer's disease pathology. Here, we report a genome-wide profiling of 5-hydroxymethylcytosine in 1079 autopsied brains (dorsolateral prefrontal cortex) of older individuals and assess its association with multiple measures of Alzheimer's...
Jinying Zhao

Data-driven energy management for electric vehicles using offline reinforcement learning

2 months 2 weeks ago
Energy management technologies have significant potential to optimize electric vehicle performance and support global energy sustainability. However, despite extensive research, their real-world application remains limited due to reliance on simulations, which often fail to bridge the gap between theory and practice. This study introduces a real-world data-driven energy management framework based on offline reinforcement learning. By leveraging electric vehicle operation data, the proposed...
Yong Wang
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